Oncology stands as the second most critical threat to human health, second only to cardiovascular disease. At Sygnature Discovery, our Translational Oncology team stands ready to address this formidable challenge head-on. We specialise in crafting bespoke, high-quality in vivo pharmacology services that are meticulously tailored to meet the unique needs of each client.
Your Partner in Precision: In Vivo Pharmacology Studies
Our dedicated team collaborates closely with you, providing unwavering support in the design, implementation, and execution of in vivo pharmacology studies. Whether you require assistance with established methodologies or seek cutting-edge approaches, we are your strategic partners on this journey.
Extensive Expertise in Oncology Models
Drawing upon an extensive array of cell line derived oncology models, our expertise encompasses a wide spectrum of disease types, including:
- Human tumour models spanning diverse disease categories
- Syngeneic tumour models for enhanced relevance
- Implantation techniques encompassing subcutaneous and orthotopic models
- Tailored model development to address unique research requirements
Unlocking the Potential of Drug Discovery
Our accomplished team of drug hunters possesses pharmaceutical-honed proficiency in a range of crucial areas:
- In-depth knowledge of various disease types
- Mastery over intricate signalling pathways
- Expertise in an array of therapeutic modalities
Designing Your Study for Success
Crafting effective study designs is our forte, encompassing essential elements such as:
- Tumour pharmacodynamics analysis
- Comprehensive assessment of normal tissue pharmacodynamics
- Thorough efficacy, dose, and schedule studies
- Development of resistance models for nuanced insights
- Versatility in dosing routes, spanning (p.o., i.p., s.c., i.v. and intratumoural) administration
- In-depth exploration of therapeutic pharmacokinetics and tolerability
- Evaluation of the therapeutic index and potential drug-drug interactions
Tailored Collaboration for Outstanding Results
We extend our collaboration to match your specific needs, whether it’s in a consultancy capacity, as an integral part of your drug discovery team, or through our fee-for-service model. Our invaluable experience in disease models and drug discovery amplifies the potential of every project we engage with.
We can work with you and your company on a consultancy basis, as a fully integrated member of your drug discovery team, or on a fee for service basis, bringing a wealth of experience in disease models and drug discovery to every customer’s projects.