Access our most up to date scientific developments and breakthroughs by downloading our scientific posters.
From validation of innovative capabilities, to the development of novel technologies and state-of-the-art chemistry, our scientists are proud to share some of their latest achievements.
25th June 2020
A HTS versus the novel immuno-oncology target HPK1 identifies a range of chemical starting points for the development of potent inhibitors
FIND OUT MORE25th June 2020
Developing sensitive arrays to facilitate hit identification of RNA modifying enzymes
FIND OUT MORE29th January 2020
A HTS for HPK1 inhibitors using a new Automation Platform and the Sygnature LeadFinder Library
FIND OUT MORE30th October 2019
Evolution of Compound Library – Screening at Sygnature Discovery
FIND OUT MORE30th October 2019
The application of Design of Experiment to optimise a spheroid model of kidney fibrosis
FIND OUT MORE30th October 2019
Development of In Vitro Models of Organ Fibrosis
FIND OUT MORE30th October 2019
Microscale Thermophoresis (MST) as a novel, alternative biophysical method for fragment screening and hit profiling
FIND OUT MORE9th October 2019
The Effect of IKKβ Gene Silencing on NFκB Signalling Using siRNA vs CRISPR/Cas9
FIND OUT MORE9th October 2019
Is Ticlopidine a Suitable Control Compound for Assessing PPB?
FIND OUT MORE27th September 2019
Kinetics of neurite growth dynamics using live cell imaging in different neuronal cell models
FIND OUT MORE26th September 2019
Identification of a Novel Small Molecule Inhibitor of the RNA Demethylase FTO using MST
FIND OUT MORE1st September 2019
Enabling Success in Lead Identification – Development of a HTS Library at Sygnature Discovery
FIND OUT MORE8th April 2019
Glutathione Trapping: Investigating Methods of Detection of Glutathione Adducts
FIND OUT MORE3rd April 2019
Development of a screening assay platform to identify inhibitors of neutrophil NETosis
FIND OUT MORE21st March 2019
Glutathione Trapping: Investigating the Effects of pH and Glutathione Concentration
FIND OUT MORE21st March 2019
Structurally-enabled progression of novel fragment hits for the epigenetic target BRD3
FIND OUT MORE20th March 2019
CT7001, a Novel Orally Bio-Available CDK7 Inhibitor, Is Highly Active in in-Vitro and in-Vivo Models of AML
FIND OUT MORE12th October 2018
Optimisation of a high throughput in vitro assay to determine the extent of brain tissue binding and the fraction unbound of potential CNS drugs
FIND OUT MORE24th September 2018
An Efficient, Multifaceted Approach to Indoleamine 2, 3-Dioxygenase (IDO1) Hit Profiling
FIND OUT MORE9th July 2018
Application of Different Neuronal Models to Investigate Glutamate-induced Excitotoxicity in Drug Discovery
FIND OUT MORE1st June 2018
Development of an in vitro Immuno-Oncology platform to aid the Development of Next Generation Cancer Therapeutics
FIND OUT MORE22nd May 2018
Lipophilicity Measurement, Prediction and Impact
FIND OUT MORE21st May 2018
Validation of Non-CYP Mediated Stability Assays
FIND OUT MORE14th April 2018
Characterisation of in vitro Models of Microglia Function to Support Neuroinflammation Drug Discovery
FIND OUT MORE28th January 2018
Synthesis of Substituted Tetrahydrofurans
FIND OUT MORE16th January 2018
Compound Profile of 61 Libraries Delivered to ELF
FIND OUT MORE27th October 2017
A Phenotypic Screen to Identify Novel Neuroprotective Agents
FIND OUT MORE6th October 2017
Assessment of the In Vivo Disposition of Cinchophen in Rat and potential mechanisms of drug-induced liver injury
FIND OUT MORE18th September 2017
Live cell and high content imaging approaches identify apoptosis inducers in cell models of triple negative breast cancer
FIND OUT MORE15th September 2017
3D Cell Assays: A Valuable Tool for Drug Discovery
FIND OUT MORE12th September 2017
The Analysis and Stabilisation of Tetrahydrobiopterin and Dihydrobiopterin
FIND OUT MORE25th June 2017
Discovery of PC945, a novel antifungal agent for inhaled administration
FIND OUT MORE30th May 2017
Analysis of the First 40 Libraries Delivered to ELF
FIND OUT MORE20th May 2017
Complementary Biophysical Approaches to Assess Fragment Binding
FIND OUT MORE4th February 2017
Adoption of High Content Imaging Capabilities in Support of Integrated Drug Discovery Programmes
FIND OUT MORE18th November 2016
Fragment-based Hit Identification for the Epigenetic Target BRD3
FIND OUT MORE25th October 2016
The use of in vitro ADME techniques in understanding fasiglifam-induced liver injury
FIND OUT MORE25th October 2016
Drug Discovery Approaches for Epigenetic Targets
FIND OUT MORE9th September 2016
Optimisation of a Series of Potent and Selective GR Antagonists
FIND OUT MORE7th June 2016
An Integrated Panel of Assays for the Prediction of Drug-Induced Liver Injury
FIND OUT MORE7th June 2016
Fragment-based Lead Discovery to Identify Novel Bromodomain-Containing Protein 3 Binders
FIND OUT MORE7th June 2016
New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma
FIND OUT MORE7th June 2016
Fragment-based Hit Discovery for the Epigenetic Target BRD3 (poster)
FIND OUT MORE28th September 2015
Cyclic Ketones as Building Blocks for Diverse Library Scaffolds
FIND OUT MORE28th September 2015
Azomethine ylide cycloadditions
FIND OUT MORE7th September 2015
PAINS Handout ELRIG Sept 2015 Notes
FIND OUT MORE5th September 2015
Dealing with PAINs in a drug discovery CRO
FIND OUT MORE8th August 2015
Heterogeneous Catalysis: A KeyTool in the Synthesis of sp3-Rich Library Scaffolds
FIND OUT MORE23rd April 2015
FTSA and SPR for identifying small molecule ligands and PAINs
FIND OUT MORE20th April 2015
From Idea to Library: The Process to Deliver 40,000 Unique Lead-like Compounds
FIND OUT MORE24th February 2015
Fragment Library Design and Screening 3
FIND OUT MORE28th July 2014
A Safer Route to Organic Azides Using Segmented Flow
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