Posters

23rd January 2025

Reducing DCM Use

26th November 2024

Serotonin Uptake and Release: Comparing (±)MDMA, Fluoxetine, and Dexfenfluramine

26th November 2024

Binding affinities of a range of psychedelics for 5-HT1A, 5-HT2A and 5-HT2C receptors in rodent brain

4th November 2024

Revisiting the serotonin binding pose of the 5-HT2A receptor with cryo-EM

11th October 2024

Radiotherapy improves efficacy of the PARP inhibitor Niraparib in a preclinical model of triple negative breast cancer

11th October 2024

Using IVIS bioluminescent imaging to assess in vivo biodistribution of HermesTM nanoparticles

9th October 2024

Humanising drug discovery with integration of automation workflows

8th October 2024

Pharmacological evaluation of the early and late phases of the mono-iodo-acetate (MIA)-induced osteoarthritic joint pain model in rats using an automated dynamic weight bearing system

7th October 2024

Functional characterization of GRIN2B variants using automated patch clamp technology

7th October 2024

Electrophysiology characterization of human CLC-1 and CLC-2 ion channels stably expressed in HEK cells using the SynchroPatch 384i automated electrophysiology platform

6th October 2024

Effects of compound targeting different mechanisms on LPS-induced neuroinflammation

6th October 2024

A high content imaging screening assay to identify novel neuroinflammation modulators using human patient iPSC derived microglia

6th October 2024

Utilizing Solid Supported Electrophysiology (SSME) to accelerate discovery of TRPML1 modulators

1st October 2024

Electrophysiological characterisation of functional and pharmacological effects of β subunit expression on BK channel activity.

27th September 2024

Modelling nicotine relapse: validating the rat intravenous self-administration model for efficacy testing novel treatments for nicotine addiction

27th September 2024

Cryo-EM for Structurally Enabled Therapeutic Antibody Development Against GPCRs

23rd September 2024

Radiotherapy sensitises preclinical models to DNA damage response agents

20th September 2024

Measurement of the ability of three compounds including (±)MDMA to stimulate uptake and release of [3H]5-HT in rat frontal cortical synaptosomes

20th September 2024

Determination of the profile of a range of psychedelics for 5-HT1A, 5-HT2A and 5-HT2C receptors in rodent brain tissue

19th September 2024

Applications of FIDA in Protein Science

17th September 2024

Exploring lysosome function in fibroblasts from Alzheimer’s and Parkinson’s disease patients: a platform for drug discovery

16th September 2024

Dedicated DMPK for Degraders – a flexible approach for flexible molecules

13th September 2024

Fast Isolation and Characterisation of Rat Oligodendrocyte Precursor Cells for Differentiation and Proliferation Studies

4th September 2024

Biotinylation of recombinant proteins by co-expression with BirA in a range of different cell hosts

27th August 2024

Methadone ameliorates the effects of morphine withdrawal in rat model of physical dependence

16th August 2024

Discovery of Novel Ligase Ligands Using Affinity Selection Mass Spectrometry

16th August 2024

Development of Antigen-specific Recall Assays to Evaluate the Effects of Immunomodulatory Drugs on Adaptive Immunity

14th August 2024

A New Method for the Synthesis of Betsylated Amino Acids Using Aqueous Buffered Sodium Hypochlorite Solution

14th August 2024

Efficient & Metal-Free Synthesis of 2,3-Disubstituted Pyridopyrimidones via Ketenimine Intermediates

7th August 2024

A Screening Platform for Immunomodulatory Compounds Targeting B Lymphocytes

15th July 2024

Early Comparison of the in vitro to in vivo Translation of Different IRAK4 Inhibitor Modalities

12th July 2024

Development of an Assay to Identify Novel Inhibitors of Neutrophil Extracellular Trap Formation (NETosis)

12th July 2024

Profiling of LPS-Induced Acute Systemic Inflammation in the Mouse

12th July 2024

Dexamethasone and TAK-242 reduce inflammation in the LPS-induced acute kidney injury (AKI) mouse model

12th July 2024

Dextran Sulfate Sodium (DSS)-induced ulcerative colitis model in mice: comparing the effects of two therapies on clinical signs and colon cytokines secretion

18th June 2024

Synthesis of Leucine-rich repeat kinase 2 Degraders for Parkinson’s Disease

11th June 2024

Unwinding the complexities of helicases as compelling drug targets in oncology

11th June 2024

Radiotherapy sensitizes preclinical models to DNA damage response agents

16th May 2024

Molecular Glue Hit Identification at Sygnature Discovery

7th May 2024

Montana Molecular Cell-based Biosensor Assays for GPCR Drug Discovery and Characterization

2nd May 2024

High Content Imaging Evos™ M7000

27th March 2024

CHARMED in Action

19th March 2024

High Content Imaging at Sygnature Discovery

11th March 2024

A Lean Optimized Fragment Library For Crystallographic Fragment Screening

11th March 2024

Building a platform of validated high throughput screening approaches for molecular glue degrader identification

21st February 2024

Fragment-Based Drug Discovery approaches to tackle emerging multi-component therapeutic targets

19th February 2024

From Donor to Data: The Critical Role of Quality Human PBMCs in Immunological Studies

22nd January 2024

High Content Imaging EvosTM M7000

22nd December 2023

Unlocking the Potential of iPSC Microglia

21st December 2023

Comparing the efficiency of two therapies on DSS-Induced Colitis in Mice: Evaluation of Clinical Signs and Pro-Inflammatory Cytokine Secretion

1st December 2023

Cell Viability & Apoptosis Assays

1st December 2023

A Preclinical PK/PD Mouse Model of LPS-induced Inflammation Permits Targeting of Inflammatory Pathways

1st December 2023

LPS-induced cytokines release PK-PD study in mice serum

1st December 2023

Protein Analysis by Capillary Electrophoresis

1st December 2023

From Paper to Assay: A Case Study on Adapting, Developing and Troubleshooting an Enzymatic Assay for High-Throughput Screening

27th November 2023

Anti-GBM serum induces early onset of autoimmune response and fibrosis in kidney of male Sprague Dawley rats.

7th November 2023

Psilocybin: the relationship between head twitch response, locomotor activity, 5-HT2A ex vivo receptor occupancy and plasma and brain levels of psilocin

2nd November 2023

Preventative effects of dexamethasone in lipopolysaccharide-induced neuroinflammation

27th October 2023

In Vitro Microglia Models as a Screening Platform to Support Neuroinflammation Drug Discovery Programs

25th October 2023

The implantation site impacts the tumour growth kinetics and tumour immune infiltrate in EO771 and 4T1 syngeneic breast cancer models

25th October 2023

Combinations of immune checkpoint inhibitors with fractionated radiotherapy or DNA damage response agents leads to improved anti-tumour responses and modulates the tumour immune microenvironment.

18th October 2023

Dexamethasone and Enalaprilat but not SB525334 exhibit anti-inflammatory properties in precision-cut kidney slices (PCKS) obtained from mice with Adriamycin-induced nephropathy

13th October 2023

Development and Validation of [3H]Cimbi-36 Binding in Mouse Frontal Cortex Including Affinity Constant Determination for Classical Psychedelics: Comparison to [3H]MDL100,907 Binding

9th October 2023

Evaluation of protein biomarkers in brain homogenate and plasma from different animal models of Alzheimer’s Disease: P301S and APP/PSEN1

3rd October 2023

What is Happening in High Throughput Screening at Sygnature Discovery?

3rd October 2023

Establishing assays to investigate combinations of fractioned radiotherapy with DNA damage response agents in vitro and in vivo to enable investigation of radiosensitisation and improved anti-tumour responses.

3rd October 2023

Chemogenomic screening of the NLRP1 pathway

27th September 2023

Assessing the effects of four clinically used analgesics in two mechanistic stimuli-evoked acute pain models in mice demonstrates good predictive nature of the phase 2 of formalin pain model.

27th September 2023

Building a Neuroscience Drug Discovery Platform

27th September 2023

Mitochondrial dysfunction, an in vitro model of neurodegenerative disorders: a focus on multiple endpoints, humanisation, and drug discovery platforms to enable new therapeutic discov

22nd September 2023

Establishing an ASMS capability to Broaden High Throughput Hit Finding Capabilities at Sygnature Discovery

19th September 2023

Characterising the response of tumours to fractioned radiotherapy and immune checkpoint inhibitors

3rd August 2023

Characterising the Irreversible: Using Biophysics to Enable Covalent Drug Discovery

3rd August 2023

Total and Phospho-Tau Levels in an Animal Model of Alzheimer’s Disease: A Cross-Platform Comparison of Biomarker Measurements

5th July 2023

Discovery of Opelconazole (PC945): A Novel Antifungal Agent for inhaled Administration

5th July 2023

Building Diverse Hit-Finding Collections Through Novel Chemistries

27th June 2023

Do current therapies target kidney inflammation?

22nd June 2023

Generation and validation of human monocyte-derived microglia (MDMi); a Sygnature Discovery screening platform for identifying novel anti-neuroinflammatory drugs

25th June 2020

Comparing HTS with the Novel Immuno-Oncology Target HPK1: Unveiling Diverse Chemical Starting Points for Potent Inhibitor Development

25th June 2020

Developing sensitive arrays to facilitate hit identification of RNA modifying enzymes

29th January 2020

HTS for HPK1 Inhibitors: New Automation Platform & Sygnature LeadFinder Library

30th October 2019

Evolution of Compound Library – Screening at Sygnature Discovery

30th October 2019

Optimising Kidney Fibrosis Spheroid Model using Design of Experiment (DoE)

30th October 2019

Development of In Vitro Models of Organ Fibrosis

30th October 2019

Microscale Thermophoresis (MST) as a novel, alternative biophysical method for fragment screening and hit profiling

9th October 2019

Comparing RNAi and CRISPR/Cas9 for Modulating Drug Targets: A Case Study on IKKβ in NFκB Signalling Pathway

9th October 2019

Is Ticlopidine a Suitable Control Compound for Assessing PPB?

27th September 2019

Kinetics of neurite growth dynamics using live cell imaging in different neuronal cell models

26th September 2019

Identification of a Novel Small Molecule Inhibitor of the RNA Demethylase FTO using MST

1st September 2019

Enabling Success in Lead Identification – Development of a HTS Library at Sygnature Discovery

8th April 2019

Glutathione Trapping: Investigating Methods of Detection of Glutathione Adducts

3rd April 2019

Development of a screening assay platform to identify inhibitors of neutrophil NETosis

21st March 2019

Glutathione Trapping: Investigating the Effects of pH and Glutathione Concentration

21st March 2019

Advancing Novel Fragment Hits for Epigenetic Target BRD3: A Structural Approach

20th March 2019

CT7001, a Novel Orally Bio-Available CDK7 Inhibitor, Is Highly Active in in-Vitro and in-Vivo Models of AML

12th October 2018

Optimisation of a high throughput in vitro assay to determine the extent of brain tissue binding and the fraction unbound of potential CNS drugs

24th September 2018

An Efficient, Multifaceted Approach to Indoleamine 2, 3-Dioxygenase (IDO1) Hit Profiling

9th July 2018

Application of Different Neuronal Models to Investigate Glutamate-induced Excitotoxicity in Drug Discovery

1st June 2018

Development of an in vitro Immuno-Oncology platform to aid the Development of Next Generation Cancer Therapeutics

22nd May 2018

Lipophilicity Measurement – Prediction and Impact

21st May 2018

Validation of Non-CYP Mediated Stability Assays

14th April 2018

Characterisation of in vitro Models of Microglia Function to Support Neuroinflammation Drug Discovery

28th January 2018

Synthesis of Substituted Tetrahydrofurans

16th January 2018

Compound Profile of 61 Libraries Delivered to ELF

27th October 2017

A Phenotypic Screen to Identify Novel Neuroprotective Agents

6th October 2017

Assessment of the In Vivo Disposition of Cinchophen in Rat and potential mechanisms of drug-induced liver injury

18th September 2017

Live cell and high content imaging approaches identify apoptosis inducers in cell models of triple negative breast cancer

15th September 2017

A Valuable Tool for Drug Discovery: 3D Cell Assays

12th September 2017

The Analysis and Stabilisation of Tetrahydrobiopterin and Dihydrobiopterin

25th June 2017

Discovery of PC945, a novel antifungal agent for inhaled administration

30th May 2017

Analysis of the First 40 Libraries Delivered to ELF

20th May 2017

Complementary Biophysical Approaches to Assess Fragment Binding

4th February 2017

Adoption of High Content Imaging Capabilities in Support of Integrated Drug Discovery Programmes

18th November 2016

Fragment-based Hit Identification for the Epigenetic Target BRD3

25th October 2016

The use of in vitro ADME techniques in understanding fasiglifam-induced liver injury

25th October 2016

Drug Discovery Approaches for Epigenetic Targets

9th September 2016

Optimisation of a Series of Potent and Selective GR Antagonists

7th June 2016

An Integrated Panel of Assays for the Prediction of Drug-Induced Liver Injury

7th June 2016

Fragment-based Lead Discovery to Identify Novel Bromodomain-Containing Protein 3 Binders

7th June 2016

New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma

7th June 2016

Poster: Epigenetic Target BRD3 – Fragment-based Hit Discovery

28th September 2015

Cyclic Ketones as Building Blocks for Diverse Library Scaffolds

28th September 2015

Azomethine ylide cycloadditions

7th September 2015

PAINS Handout ELRIG Sept 2015 Notes

5th September 2015

Dealing with PAINs in a drug discovery CRO

8th August 2015

Heterogeneous Catalysis: A KeyTool in the Synthesis of sp3-Rich Library Scaffolds

23rd April 2015

FTSA and SPR for identifying small molecule ligands and PAINs

20th April 2015

From Idea to Library: The Process to Deliver 40,000 Unique Lead-like Compounds

24th February 2015

Fragment Library Design and Screening 3

28th July 2014

A Safer Route to Organic Azides Using Segmented Flow