Chemistry

The engine driving most small molecule discovery programs is the biological chemistry and drug discovery team.

Sygnature’s chemistry department is one of the largest and most experienced medicinal chemistry groups in the UK with over 85% of chemists possessing a PhD. It has provided expert synthetic, analytical and medicinal chemistry resource to multiple successful client programs.

Biological Chemistry and Drug Discovery

Our medicinal chemists work closely with computational chemistry, bioscience and DMPK teams to assemble a project-specific screening cascade that addresses the key challenges at each stage of the project. Our close proximity and state of the art informatics system allows a very rapid design-make-test-analyse cycle to efficiently inform decision making.

Sygnature’s team has frequently been finalists in the UK retro-synthesis competition and this high level of innovative chemistry allows us to tackle even the most challenging medicinal programs. Our investment in modern analytical instrumentation provides our chemists with the tools needed to isolate and fully characterise the molecules we make.