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Sygnature Discovery > Drug Discovery > Bioscience > Biochemical Assays

Biochemical Assays

Our bioscientists are well versed in the development and maintenance of robust tailored assays spanning a plethora of enzyme targets.

Sourced, either off the shelf from commercial vendors or developed in-house to fit our clients’ requirements, our experienced scientists provide high-quality biochemical assays and informed data interpretation across the discovery pipeline.

We can offer a variety of scalable enzyme activity assays (product formation and detection) and Binding Assays using industry-standard instrumentation platforms across multiple enzyme classes.

Enzyme Activity Assays:

  • Kinase
  • Methyltransferase
  • HDAC/HAT
  • Demethylase
  • Protease
  • PDE
  • Phosphatase
  • DUB
  • Others

Binding Biochemical Assays:

  • Radiolabel binding
  • Fluorescence Polarisation (FP) binding assays
  • Nuclear Hormone
  • Ion Channels
  • Others

Technologies:

  • BRET (bioluminescence resonance energy transfer), NanoBRET™, HTRF (homogeneous time-resolved fluorescence).
  • Fluorescence Intensity, Absorbance, Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET), LC-MS (liquid chromatography–mass spectrometry).
  • AlphaScreen® (amplified luminescent proximity homogeneous assay).
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Biochemical Assays Services

Enzymology

Rely on our expert scientists proficient in enzymology, skilled in optimising activity, characterising enzyme kinetics, and elucidating mechanisms of inhibition. Trust us to provide high-quality data that informs your discovery program effectively.

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Binding Assays

Maximise the potential of your project with Sygnature Discovery's renowned team of bioscientists. Drawing on their extensive experience, we specialise in developing a wide range of binding assays in various formats. Trust us to provide the tailored assay solution that precisely matches your project's unique needs.

DISCOVER