Synthetic Chemistry

Designing an efficient and practical synthetic route to target molecules can be a complex task. Balancing considerations such as reaction selectivity, yield, scalability, and cost effectiveness while achieving the desired chemical transformations often requires creativity and extensive knowledge on synthetic methodologies.

Sygnature Discovery have expertise in both classical and modern transformations, as well as significant experience in a broad range of specialist areas and access to state-of-the-art facilities in our custom-built laboratories.

We have a proven track record of solving challenging synthetic chemistry problems in new and creative ways, opening the scope of chemical space available for projects and generating novel intellectual property.

Sygnature can provide:

• Technologies such as the use of electronic lab notebooks, automated purification kit, access to LCMS/UPLC in each of our purpose-built labs or the presence of our own high-field NMR spectrometers, allowing our scientists to rapidly achieve their goals.
• Extensive experience in performing and optimising library chemistry, alongside our in-house automated purification, liquid handling and sample tracking technologies for rapid synthesis of targeted arrays.
• Our Liberty 1 CEM machine provides the capacity to perform rapid automated peptide synthesis to routinely prepare 20-30 mers on ~0.3 mmol scale.
• Our previous portfolio has also included work on carbohydrates, nucleosides, macrocycles, pro-drug and protac linker technologies, as well as solid-phase and lipid chemistries.
• In-house metered delivery systems and a range of custom-built high-pressure vessels enable gas-phase chemistries, including hydrogenation, ozonolysis and carbonylation.
• Large-scale batch reactors, allow us to transition compounds from mg to 100g scale on site, providing batches for non-GLP safety studies and process ready routes through technology transfers to 3rd parties.
• Individual access to online databases and patent literature assists each of our chemists in trouble-shooting synthetic issues as efficiently as possible and in generation of novel chemical entities.
• A dedicated team of procurement specialists negotiate efficient sourcing of reagents and consumables to control project costs.