Our in-depth bioscience knowledge of target biology, therapeutic area specialism, and experience of working collaboratively at each stage of the drug discovery pipeline allows the efficient design and implementation of tailored high-quality assays, which help to accelerate your drug discovery programs.

Our bio scientist team is staffed by highly experienced bio scientists (over 80% PhDs), many with 10-20 years of drug discovery experience gained in pharmaceutical research (from AstraZeneca, Takeda, GSK, Merck, Novartis, Pfizer, Prosidion and many more).  More than 25% of the department has over 15 years’ first-hand industry experience in discovering new drugs, both small molecules and biologicals across a broad range of therapeutic areas and biological target classes.  Your drug discovery projects are in safe hands at Sygnature Discovery.

  • We can assist you in screening your novel compounds for a range of project-specific properties, such as cellular function and isolated target engagement characteristics.
  • Utilise the very latest technologies to minimise the risk of drug failure later in the drug discovery pipeline.
  • Offer a broad spectrum of adaptable capabilities to help you reach success with your drug discovery target in a variety of therapeutic areas.

As bio scientist pride ourselves in delivering high-quality consistent assay data to measure Structure-Activity Relationships (SAR) and define compound Mechanism of Action (MOA) to help drive your project forward.  All project data linked to experimental write-ups are stored within a powerful online Dotmatics-based web portal that gives secure access to your biological data regardless of your geographical location.

Sygnature Discovery’s Bioscience Department forms part of the talented Integrated Drug Discovery team that can enhance your drug discovery project at any stage of the process.  You will benefit from being able to access bench bioscientists directly and our bioscientist work collaboratively to address scientific needs so that your drug discovery program is given the best opportunity for success.

We have established a broad range of industry-standard in-house capabilities including bioscience, which complemented by cutting-edge technology platforms and supported by our in-depth drug discovery expertise, allow us to add value to your drug discovery program. Our team is continually enhancing the suite of capabilities available to you, mirroring the evolving discovery landscape, always ensuring that the technical expertise and drug discovery know-how underpin each of our platforms.

Bioscience Services

Assay Development

At Sygnature Discovery, we leverage decades of experience to design, implement, and maintain project-tailored in vitro screening cascades. From Target Validation to Lead Optimisation and candidate nomination, our comprehensive assay development services ensure the success of your project at every stage.


Custom Cell Line Generation

With over two decades of experience, Sygnature Discovery excels in custom cell line generation. Having completed 200+ successful projects and produced 400+ cell lines, we stand as your reliable partner in this service. Our specialisation includes ion channels, receptors, and more. We adopt a collaborative approach and employ streamlined processes, delivering robust reagents that guarantee efficient and dependable research initiation.


Ion Channel Screening

Our scientists can provide you with innovative and customisable ion channel screening services that deliver meaningful data.


Drug Screening

Sygnature offers scalable hit identification screening methodologies, including high-content and fragment screens. We specialise in developing customised and efficient screening assays to bolster discovery programs across diverse therapeutic areas.


Cell Based Assays

Sygnature Discovery offers a range of cutting-edge 2D and 3D cellular assays to assess the impact of your target on various phenotypic endpoints. Our capabilities include real-time and high-resolution assessment techniques such as live cell imaging, high content imaging, and flow cytometry, utilising a diverse array of primary and immortalised cell types.


Biochemical Assays

Sygnature Discovery offers tailored biochemical assay development using multiple formats for relevant drug discovery ventures.


Biophysical Assays

Discover precise compound binding insights throughout drug discovery here at Sygnature Discovery. Our biophysicists employ advanced technologies for comprehensive characterisation.


Biomarker Discovery

Sygnature Discovery have a diverse range of sensitive biomarker detection platforms and assays that can be used to develop and validate biomarkers for your drug target.


Primary Tissues

Sygnature Discovery has Human Tissue Act (HTA) accreditation, an internal blood donor panel and access to human and animal primary tissues from accredited biobanks and commercial vendors to provide physiologically relevant support to your project.