DMPK
DMPK studies are crucial in drug discovery and development bring integral in predicting human exposure and clinical efficacy. Concentrating research efforts on identifying DMPK-related failures early in the process leads to significant savings in both cost and time for research programs.
Expert DMPK Services
Sygnature Discovery’s DMPK services for drug discovery span across three sites Alderley Park, Nottingham and Montreal, combining the expertise of our senior scientists gained in big pharma, biotech, CROs and academia. With proven experience in DMPK our scientists offer detailed DMPK data interpretation to guide decision-making in drug programs.
By leveraging in vitro DMPK services, in vivo DMPK services, bioanalysis, biotransformation, modelling and simulation, and formulation support, we foster strong client collaboration and design custom studies that meet specific project needs. This bespoke approach improves data relevance, thereby allowing data informed decisions to improve project success rates.
Tiered Approaches to Compound Progression
Working closely within Sygnature’s global scientific network – the flexibility we have in what DMPK tools and when we employ them allows DMPK to support each individual medicinal chemistry program to identify potential issues and address them appropriately. We collaborate with customers to understand:
- The target product profile
- Essential drug properties required to meet the medical need
- Critical success factors defined by the customer
Our DMPK Offerings
- Integrated drug discovery solutions, ensuring DMPK plays a key role throughout research
- Preclinical DMPK studies, supporting early-stage compound assessment
- Standalone Fee-for-Service (FFS) contracts (in vitro & in vivo) with continued Client Services support
- DMPK consultancy, offering expert interpretation for strategic guidance
State-of-the-Art Analytical Equipment for DMPK Studies
Our facilities feature a wide range of advanced analytical instruments from several leading vendors to support our DMPK studies. These include state-of-the-art mass spectrometry platforms and complementary technologies that deliver the sensitivity, accuracy and reliability for high-quality data. This diverse instrumentation allows us to tailor workflows to suit the specific requirements of each project.