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High Throughput Chemistry

Sygnature has a well-established HTC (High Throughput Chemistry) lab which has been efficiently producing small, diverse libraries for the European Lead Factory for the past 5 years.

In the past 5 years Sygnature has produced over 40,000 drug-like molecules with novel three-dimensional character. Our expertise in High Throughput Chemistry is also available to client projects and is especially useful in the hit-to-lead stage of the drug discovery process to rapidly expand hits and explore structure activity relationships.

  • Fully automated process for synthesis, purification and QC
    • Robotic reformatting at each stage
  • Each product traceable throughout the process by barcoded vials
    • Eliminates human / typographic errors
  • Mass-directed purification (ELS/UV option)
    • Single tube collection – compatible with wide range of structures/chromophores
  • Refined protocols for a range of robust reactions
    • Ambient to high temperature, wide range of solvents,
    • Homogeneous and heterogeneous methodologies

Progress in the early stages of Lead Identification and Lead Optimisation can be greatly accelerated by use of this advanced technology.

Get in Touch

For more details on how we can provide innovative support to your project please use this contact form.

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