High quality DMPK studies are at the heart of a successful drug discovery project. Done right, they can have a substantial impact on the development timeline, total cost of the project, and quality of the molecules that progress to the clinic.
At Sygnature we have built a DMPK team with a wealth of drug discovery experience. This enables us to do more than just deliver accurate DMPK data: we provide expert analysis and interpretation of the results. This is a key feature in helping drive your project forward.
We offer an extensive range of validated in silico, in vitro and in vivo DMPK services for drug discovery, backed up by a comprehensive portfolio of analytical techniques. We can design flexible DMPK screening cascades to support medicinal chemistry programmes, including bespoke method development.
Working closely with Chemistry and Bioscience, our approach is one of collaboration, partnering with clients to develop a greater understanding of the target and the properties that a successful drug should have. Expert guidance and problem-solving suggestions from our experienced team will help you optimise potential drug molecules, increasing the likelihood of success.
- Physicochemical profiling
- In vitro ADME
- In vivo pharmacokinetics
- PK and Bioanalysis
- Metabolite identification and biotransformation
- IVIVE and human PK predictions
- Consultancy services
- Discovery toxicology