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DMPK

High quality DMPK studies are at the heart of a successful drug discovery project. Done right, they can have a substantial impact on the development timeline, total cost of the project, and quality of the molecules that progress to the clinic.

At Sygnature we have built a DMPK team with a wealth of drug discovery experience. This enables us to do more than just deliver accurate DMPK data: we provide expert analysis and interpretation of the results. This is a key feature in helping drive your project forward.

We offer an extensive range of validated in silico, in vitro and in vivo DMPK services for drug discovery, backed up by a comprehensive portfolio of analytical techniques. We can design flexible DMPK screening cascades to support medicinal chemistry programmes, including bespoke method development.

Working closely with Chemistry and Bioscience, our approach is one of collaboration, partnering with clients to develop a greater understanding of the target and the properties that a successful drug should have. Expert guidance and problem-solving suggestions from our experienced team will help you optimise potential drug molecules, increasing the likelihood of success.

DMPK Services:

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DMPK Services

DMPK Consultancy

Sygnature Discovery offers a range of DMPK consultancy services to drug discovery research teams within the academic, pharmaceutical, biotechnology, charity and CRO sectors as well as to life science venture capital funds.

DISCOVER

Physicochemical Profiling

It is well understood that poor physicochemical properties are associated with increased failure of drug candidates within the pre-clinical and clinical development process. Assessing these parameters during the discovery optimisation process is critical.

DISCOVER

In silico and PBPK modelling

Working with your full project team, Sygnature’s experienced modelling and simulation team provides guidance throughout the lifetime of your project, helping to: define early discovery screening cascades, interpret in vitro data and recommend options for progression to in vivo studies. make recommendations of dose and dosing regimen for pharmacodynamic (PD) studies through PK and PK/PD...
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DISCOVER

In Vitro ADME

The assessment of the Absorption, Distribution, Metabolism, and Excretion (ADME) properties of compounds is a critical component is supporting the development of compounds within Discovery and Development. 

DISCOVER

In Vivo Pharmacokinetics (PK)

At Sygnature Discovery we offer services to support your non-GLP in vivo Pharmacokinetics studies in preclinical species including the planning of these studies and the analysis of any samples generated by UPLC-MS

DISCOVER

Bioanalysis

Sygnature’s state-of-the-art non-GLP bioanalysis service brings together the latest instrumentation and technology, which, combined with the wealth of experience across the team, is used to provide quantitative measures of metabolites for the purpose of pharmacokinetics, toxicokinetics, bioequivalence and exposure-response studies. Whilst semi-quantitative analysis (i.e. without the use of an external calibration curve) allows the cost-effective...
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DISCOVER

Metabolite Identification (Met-ID)

Metabolites are identified using the skill and experience of our dedicated team, bringing many years of experience into client collaborations. This allows manual data processing on a scan-by-scan basis without the need to use Met-ID software packages which, depending on how the software is configured, can miss the more unusual metabolites and generate a large...
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DISCOVER

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