Journal Papers

At Sygnature Discovery we pride ourselves on being innovative and forward-thinking. We invest in the most cutting-edge technologies to deliver the best science that makes a difference to our clients.

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Our scientists have the expertise and the enthusiasm that often translates into novel and exciting scientific discoveries. Get up to date with our scientific breakthroughs by accessing our latest scientific publications.

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Molecularly profiled trials: toward a framework of actions for the “nil actionables”

Molecularly profiled trials for 'nil actionables' in cancer treatment. Dr. Allan Jordan suggests a framework for better therapeutic opportunities through data engagement

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Impact of Mitochondrial Targeting Antibiotics on Mitochondrial Function and Proliferation of Cancer Cells

Impact of Mitochondrial Targeting Antibiotics on Mitochondrial Function and Proliferation of Cancer Cells

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Targeting p300/CBP axis in lethal prostate cancer

Targeting p300/CBP axis in lethal prostate cancer

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Sensitivity of Binding Free Energy Calculations to Initial Protein Crystal Structure

Miroslav Suruzhon, Michael S Bodnarchuk, Antonella Ciancetta, Russel Viner, Ian D Wall, and Jonathan W Essex Abstract: Binding free energy calculations using alchemical free energy (AFE) methods are widely considered to be the most...

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High Throughput Screening: Methods, Techniques and Applications (Chapter 7)

Discover High Throughput Screening (HTS) in drug discovery. Expert insights, methods, and applications for successful hit identification. Essential knowledge for researchers in today's and future laboratories.

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Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia

Uncover a novel anti-leukaemic compound derived from parthenolide, addressing drug-resistant CLL.

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Synthesis of a hexahydropyrrolo indole (HPI) compound library

Synthesis of a Hexahydropyrrolo Indole (HPI) Compound Library: Creating a diverse 276-member library based on HPI scaffold.

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Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

Scaffolds of natural products represent promising starting points for the development of focused compound libraries

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Narrow Spectrum Kinase Inhibitors: Treating COPD and Steroid-Resistant Asthma

Experience therapeutic potential with narrow spectrum kinase inhibitors for COPD and steroid-resistant asthma.

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Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective

Karawajczyk A., Giordanetto F., Benningshof J., Hamza D., Kalliokoski T., Pouwer K., Morgentin R., Nelson A., Müller G., Piechot A., Tzalis D. Abstract High-throughput screening (HTS) represents a major cornerstone of drug discovery. The...

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Expedient Synthesis of an Atypical Oxazolidinone Compound Library

Experience the expedient synthesis of an atypical oxazolidinone compound library. Uncover an efficient approach for generating diverse compounds, offering potential for drug development and research.

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In vitro and in vivo antifungal profile of a novel and long-acting inhaled azole, PC945, on Aspergillus fumigatus infection

In vitro and in vivo antifungal profile of a novel and long-acting inhaled azole, PC945, on Aspergillus fumigatus infection

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