Degraders on The Rise – Targeted Protein Degradation in Drug Discovery
With Dr Roland Hjerpe, Senior Scientist, Bioscience
The concept of Targeted Protein Degradation (TPD) covers all techniques that exploit the natural mechanisms of cellular degradation to target a disease-causing protein for destruction. The power of TPD, at least in principle, is that it allows the pursuit of what have previously been thought of as “undruggable” targets. But what are the different modalities of TPD, and, importantly, what should be considered when evaluating it as an approach?