Archives

Substance Use Disorders: Identifying new Treatments for Opioid Abuse

Adulteration of opioids with fentanyl and nitazenes has, in part, been responsible for the huge increase in drug related deaths...
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From Dinosaur Heresies to Neuroplastogen’s

Sometimes things need shaking up. When I read Robert Bakker’s book the ‘The Dinosaur Heresies’ I was hooked, although my...
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Do Ligands Dream of Degrader Fame? Rapid Direct-to-Biology generation of PROTACs!

PROTACs, formally known as heterobifunctional degraders, remain an exciting modality for tackling disease-linked proteins long considered “undruggable.” By inducing the...
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Exploring the Lifelines of the Brain: Autophagy and Lysosomal function at the Heart of Neurodegeneration

The human brain, a marvel of complexity and sophistication, is the epicentre of our consciousness, cognition, and overall well-being. It...
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Delivering for ALS patients: ‘Good Decision Tools’ in Research are good for patients and good economics

Amyotrophic lateral sclerosis (ALS) is a fatal late-onset neurodegenerative disorder which affects motor neurons in the brain and spinal cord....
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Sygnature Discovery Partners with Insmed to develop first-in-class compounds for genetically defined diseases

Sygnature Discovery collaborates with Insmed, bringing together their expertise to develop compounds targeting genetically defined diseases. With seamless teamwork and co-located scientific operations, they aim to create innovative therapeutics for unmet medical needs.

Synthetic chemistry in focus at From Farm to Pharma

We were pleased to host the final ELRIG networking event of 2021 last month at Alderley Park. Synthetic chemistry has...
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Tips for success in candidate profiling – and beyond

Candidate profiling, or late lead optimisation, is the final stage of de-risking and optimising drug candidates with the best chance...
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Formulating for success: A game-changing new facility

This month sees the official opening of our new Form and Formulation department. But why are we bringing formulation scientists...
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Hitting the drug target takes teamwork

Drug discovery programmes can be made or broken by the approaches organisations take in the early stages. As project viability...
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