Show results for
  • Sygnature
  • News
  • Drug Discovery
  • Therapeutic Areas
  • Events
  • Vacancies

ZDF Rat Model of Diabetic Nephropathy

Zucker diabetic fatty (ZDF-Leprfa/Crl) rats exhibit obesity, insulin resistance, impaired glucose tolerance, hypertension, and renal and cardiovascular disease due to deficits in leptin signalling. The ZDF rat model develops a phenotype very similar to humans with type 2 diabetes , including the existence of diabetic nephropathy. 

The progressive diabetes in Zucker diabetic fatty (ZDF-Leprfa/Crl) rats leads to a decline in renal function.

ZDF-Lepr fa/Crl rats show glomerular and tubulointerstitial damage with string hydronephrosis, tubular atrophy/dilation, hyaline casts and retraction of glomerular tufts

The ZDF rat displays progressive hyperglycaemia and elevated blood HbA1c


The ZDF rat displays significantly increased urinary glucose excretion

Get in Touch

For more details on how we can provide innovative support to your project please use this contact form.

CTA Form

Areas of interest

Discovery Discipline
Therapeutic Areas
The information you supply will be processed in accordance with the General Data Protection Regulation (EU) 2016/679. For further details about how Sygnature Discovery collects, uses and stores personal data, please refer to our Website Privacy Notice available here.