Show results for
  • Sygnature
  • News
  • Drug Discovery
  • Therapeutic Areas
  • Events
  • Vacancies

Self-administration

Intravenous self-administration in rats is an extremely reliable predictor of the risk of abuse by humans and this test forms an integral component of the non-clinical package that is part of the regulatory evaluation for all CNS active drugs.

  • We provide GLP-compliant intravenous self-administration testing in rats for evaluation of the reinforcing potential of drugs. Experience with a wide range of drugs including stimulants, opioids, nicotine, MDMA and other entactogens, NMDA antagonists, cannabinoids, and benzodiazepines.
  • Fixed and progressive ratio schedules of drug reinforcement
  • ‘Break-point’ analysis to quantify the relative reinforcing effects of drugs

In this model rats are trained to self-administer a known drug of abuse and the ability of the test compound to maintain responding is subsequently determined. Selection of an appropriate training drug is a critical aspect of the study design and is something Sygnature experts are well-positioned to advise on.

Heroin or cocaine maintain self-administration under a fixed-ratio schedule of reinforcement in rats

Assessment of reinforcing efficacy using a progressive-ratio schedule in rats

 

Get in Touch

For more details on how we can provide innovative support to your project please use this contact form.

CTA Form

The information you supply will be processed in accordance with the General Data Protection Regulation (EU) 2016/679. For further details about how Sygnature Discovery collects, uses and stores personal data, please refer to our Website Privacy Notice available here.