Show results for
  • Sygnature
  • News
  • Drug Discovery
  • Therapeutic Areas
  • Events
  • Vacancies

Body composition analysis to determine specificity of weight loss

Body composition analysis can be used to investigate whether weight loss is accounted for by a clinically beneficial selective loss of fat, or by producing non-specific decreases in water (dehydration) and/or protein content (muscle wasting or cachexia)., which can be harmful.

In-life assessment of body composition in mice can be performed under light anaesthesia by dual-energy X-ray absorptiometry (DEXA). In addition, a terminal carcass composition (mouse and rat) can be performed by gold-standard chemical methods (for the assessment of fat, protein, water and ash) or by a near-infra-red analysis (FoodScan™; rat only; for the assessment of fat, protein and water).

Longitudinal DEXA measurement of body composition in DIO mice given rimonabant or switched to a low-fat diet

Get in Touch

For more details on how we can provide innovative support to your project please use this contact form.

CTA Form

The information you supply will be processed in accordance with the General Data Protection Regulation (EU) 2016/679. For further details about how Sygnature Discovery collects, uses and stores personal data, please refer to our Website Privacy Notice available here.