Assessment of gastric emptying rate to explore mechanisms of satiety and reduced food intake
The inhibition of gastric emptying has been linked to satiety and reduced food intake. We offer direct (phenol red recovery) and indirect (serum APAP) models of gastric emptying, depending on your project requirements. This allows the ability of drugs to inhibit gastric emptying to be evaluated. Both models have been validated using the clinical opioid agonist loperamide, which decreased gastric emptying compared to control animals.
Loperamide Inhibits gastric emptying in a dose-dependent manner in mice (measured directly using the Phenol Red method)
Loperamide Inhibits gastric emptying in a dose-dependent manner in rats (measured indirectly using the serum APAP method)
We also provide a solid food model to investigate the ability of drugs to inhibit gastric emptying.