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Acute feeding studies

Acute feeding studies  provide an excellent screening platform to quickly understand the hypophagic potential of a novel drug.

These assays are typically performed in  lean mice or rats but can also be performed in a variety of animal models, such as the DIO mouse. Following acute administration, the effect of the novel test drug on food intake is evaluated. Where a delayed onset of drug effect is forecast, dosing can continue for up to 7 days.

An example of an acute study set up is as follows, for mice and rats:

  • Drugs can be administered by various routes (e.g. po, sc, ip, iv)
  • Mice or rats are acclimatised to palatable wet mash (4 h/day). Drugs are administered before mash and food intake is measured subsequently.
  • Rats are maintained under reverse-phase lighting with free access to normal, powdered rat chow. Drugs are given at the onset of the dark photoperiod and food intake is measured for up to 24 h.
  • Determination of ED50 values for inhibition of food intake
  • Blood sampling for pharmacokinetic analysis (at the end of studies or from satellite groups of animals)

 

Sibutramine reduces acute food intake (mean mash consumption) in a dose-dependent manner in mice

Sibutramine reduces acute food intake in a dose-dependent manner in rats

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