Molecular Glue Hit Identification at Sygnature Discovery

At Sygnature Discovery, we are developing novel approaches for the discovery of molecular glue degraders. This poster highlights the use of surface plasmon resonance (SPR) for the identification of molecular glues from compound libraries. We have demonstrated this approach by screening 10,000 lead-like compounds and 1,300 fragments for glue properties, using the Cereblon ubiquitin ligase and SOS1 and SHP2 proteins, as a model system.

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