Heterogeneous Catalysis: A KeyTool in the Synthesis of sp3-Rich Library Scaffolds

Abstract

Heterogeneous catalysis is a powerful tool in synthetic organic chemistry. Reductions utilising hydrogen can be used to generate sp3-centers from unsaturated precursors and unmask functional groups. These transformations are atom-efficient, scalable and often require no purification. The range of catalysts and supports available means that reactions can be optimised to perform the desired transformation selectively. We believed that heterogeneous catalysis would allow the preparation of several sp3-rich cores suitable for library production in the ELF project.