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Glutathione Trapping: Investigating the Effects of pH and Glutathione Concentration

Some xenobiotics can show idiosyncratic toxicity due to the formation of reactive metabolites. Glutathione (GSH) can be used as a marker for such reactive species by covalently binding to electrophilic sites via the thiol sulphur. Glutathione is known to be acidic so we have investigated the effect of GSH concentration and pH on the formation of GSH adducts and metabolic activity of human liver microsomes.

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