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From Idea to Library: The Process to Deliver 40,000 Unique Lead-like Compounds

Abstract

The ELF is a €200M project (supported by the Innovative Medicines Initiative and European Federation of Pharmaceutical Industries and Associations (EFPIA)) that aims to promote drug discovery in Europe by producing a new collection of 500,000 drug-like compounds for high throughput screening (HTS) by the public sector in a variety of therapeutic areas.

  • 300,000 compounds have been donated by EFPIA partners.
  • 200,000 compounds are being designed, generated and synthesised equally by Sygnature Discovery and four other SMEs in collaboration with academia.
  • The new libraries being synthesised will focus on: novelty, shape (eg. sp3-rich cores), diversity potential and innovative library design and will complement classical compound collections.

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