Comparing HTS with the Novel Immuno-Oncology Target HPK1: Unveiling Diverse Chemical Starting Points for Potent Inhibitor Development

High Throughput Screening (HTS) System for Hit Identification at Sygnature Discovery

At Sygnature Discovery, we have recently implemented a new, state-of-the-art High Throughput Screening (HTS) system, designed to complement our existing hit finding capabilities.

Advanced HTS System for Rapid Hit Identification

The integration of HighRes Biosolutions automation platform, Titian Mosaic compound management software, and Genedata data processing enables rapid and robust hit identification from our custom-designed LeadFinder library of 150k compounds. Discover the capabilities of this system through our robust screening cascade.

New Starting Points for HPK1 Inhibitor Development

The HTS system has successfully identified several new starting points for HPK1 inhibitor development. These structures show differentiation from those in the reported HPK1 patent literature.