📣New eBook: Explore the emerging trends shaping next-gen ADC development: Next-Generation Antibody Drug Conjugates

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  • Integrated Drug Discovery

    Integrated Drug Discovery

    Overview

    We deliver truly integrated drug discovery programs. Our co-located teams accelerate compounds from target ID to candidate.

  • Target Identification & Validation

    Target Identification & Validation

    It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.

  • Hit Identification

    Hit Identification

    Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.

  • Hit-to-Lead

    Hit-to-Lead

    High-quality hits with early proof of concept are de-risked and profiled, ready to accelerate your program towards lead optimization.

  • Lead Optimization

    Lead Optimization

    Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.

Featured Resources

  • Modalities

    Modalities

    Overview

    Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.

  • Small Molecules

    Small Molecules

    Expert small molecule discovery from target ID to scale-up, delivering candidates designed for success and market impact.

  • Peptides

    Peptides

    Transforming complex peptide concepts into next-generation therapies through integrated design, advanced analytics, and collaborative end-to-end discovery expertise.

  • Targeted protein degradation

    Targeted protein degradation

    Leveraging induced proximity and CHARMED technology to rapidly design, test, and optimize degraders for previously ‘undruggable’ targets.

  • ADCs

    ADCs

    Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.

  • Biologics

    Biologics

    Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.

Featured Resources

  • Therapeutic Areas

    Therapeutic Areas

    Overview

    Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.

  • Oncology and Immuno-Oncology

    Oncology and Immuno-Oncology

    Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.

  • Inflammation and Immunology

    Inflammation and Immunology

    Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.

  • Neuroscience

    Neuroscience

    Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.

  • Metabolic Diseases

    Metabolic Diseases

    Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.

Featured Resources

  • CellCentric Lead Optimization Campaign - CCS1477

    CellCentric Lead Optimization Campaign - CCS1477

    Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesized and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.

    Case study
  • About Sygnature

    About Sygnature

    At Sygnature Discovery, we deliver world-leading drug discovery solutions to accelerate your compound from idea to clinic.

  • Meet our Team

    Meet our Team

    Our leadership team brings diverse experience and insight, driving collaboration and innovation across drug discovery.

  • Careers

    Careers

    Explore careers at Sygnature Discovery and join a global team committed to science, collaboration, and integrity.

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Blog
The Nature of Codon Optimization
Codon optimization has become a widely used tool in recombinant protein production, helping researchers…
Journal Papers
Development of Selective Phosphatidylinositol 5‐Phosphate 4‐Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode
Helen K. Boffey, Timothy P. C. Rooney, Henriette M. G. Willems, Simon Edwards, Christopher…
Blog
Thermofluor Stability Assays: More Than Just Measuring Protein Melting Temperature
Protein stability is a critical factor in many areas of drug discovery, influencing protein…
Blog
When Proteins Don’t Behave as Predicted: The Value of Understanding Protein Charge
Modern recombinant protein expression technologies have transformed protein production. With a wide range of…
Journal Papers
Beyond Cytotoxic Payloads for Antibody Drug Conjugates – A Medicinal Chemistry Perspective
Allan Jordan, Stuart Best, and Joshua Greally Abstract Despite significant research and…
Case Studies
Cautionary Tales: Identifying Hidden Challenges in Insect Cell Protein Production
The Challenge Baculovirus expression systems are widely used to produce secreted, intracellular, and membrane…
Case Studies
Producing and Characterizing a Heterotrimeric Protein Complex for Screening and Biophysical Studies
The Challenge A client required both biotinylated and non-biotinylated forms of a heterotrimeric protein…
Case Studies
Generating a Crystallography-Ready Secreted Protein Through Construct and Glycosylation Optimization
The Challenge A client required more than 2 mg of a novel secreted protein…
Case Studies
Supporting SPR Studies by Optimizing Protein Stability and Biotinylation
The Challenge A client required a nuclear receptor protein to support surface plasmon resonance…
Case Studies
Using the BacMam System in HEK293-6E Cells
In this case study Sarah Beck outlines…
Case Studies
What Happens to Muscle During Incretin Treatment? Exploring Tirzepatide’s Impact on Muscle Mass in a Preclinical Model of Obesity
Beyond the DIO model, successful obesity therapies require more than just a demonstration of…
Blog
3 Transformative Changes in ADC Development Over the Next Decade
Catch up on our ADC development series on YouTube to…
Blog
Linker Technologies in ADCs: How They Impact Efficacy & Stability
Catch up on our ADC development series on YouTube to…
Blog
What’s the Evolving Role of Medicinal Chemistry in ADC Development?
Catch up on our ADC development series on YouTube to…
Blog
Exploring New Paths in ADC Development
Catch up on our ADC development series on YouTube to…
Blog
Toxicity & Efficacy in ADCs: How to Get it Right
Catch up on our ADC development series on YouTube to…
News
Sygnature Discovery establishes DEL screening collaboration with X-Chem
We have established a formal collaboration with X-Chem, a data-driven drug discovery company and…
Blog
Anti-inflammatory ADCs: borrowing from oncology to fix immunology’s problem
Antibody-drug conjugates (ADCs) were originally developed for cancer…
Blog
From Caterpillars to Cutting-Edge Science: The Story of Baculoviruses in Recombinant Protein Production
Have you ever taken a step back from the bench and asked “hang on a…
Blog
Navigating CNS Drug Discovery Through Cellular Pharmacology
Few areas of drug discovery are as challenging as neuroscience.
Case Studies
Producing Homotrimeric Proteins
Many proteins exist and function as multimers in their native state. However, the mechanism by…
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