Featured Resources
-
STORM Therapeutics: From Lead to Pre-Candidate Nomination in 18 Months
STORM Therapeutics: From Lead to Pre-Candidate Nomination in 18 Months
Case study
scientific solutions
Sygnature Discovery delivers world-class scientific expertise and flexible services across every discipline in drug discovery.
Our scientists work as an extension of your team, powered by AI, automation, and a shared commitment to your success. We are ready to partner with you, from targeted project support to fully integrated discovery programs.
7
0
%
of our scientists hold PhDs
3
fully integrated drug discovery hubs in UK and North America
6
0
+
novel pre-clinical and 35+ clinical compounds delivered since 2011
Supporting Your Research
At Sygnature Discovery, we support every stage of drug discovery, offering specialist services that adapt to your needs whether you’re solving a specific challenge or running a full discovery program.
Our highly skilled scientists work as an extension of your team, combining deep expertise in the core drug discovery disciplines with AI, machine learning, and automation to deliver faster, smarter results.
We offer standalone and integrated scientific solutions across bioscience, protein science & structural biology, medicinal chemistry, computer-aided drug design (CADD), drug metabolism & pharmacokinetics (DMPK), form & formulation, and in vivo pharmacology.
Whether you need focused support for a specific challenge, or specialist input to complement your internal capabilities, we tailor our approach to your goals. With Sygnature, you gain more than a service provider, you gain a trusted scientific partner committed to delivering meaningful results and advancing your high-quality candidates to clinic.
Our Scientific Solutions
We provide flexible access to exceptional scientific talent, tailored to projects of any size or complexity. Our scientists are supported by advanced AI tools that streamline workflows and improve decision-making. Whether you’re solving a specific challenge or scaling up a program, we deliver agile, high-impact solutions that move your science forward.
Computer Aided Drug Design (CADD)
Our team of over 35 scientists draws on decades of experience to help you design smarter compounds and make faster decisions by combining AI-powered modeling, scientific expertise, and secure, collaborative data access. We solve complex challenges and accelerate your drug discovery journey.
Protein Science and Structural Biology
With over 65 protein scientists at Sygnature Discovery globally, we take pride in providing high quality, fully characterized proteins for a wide range of applications such as enzymatic assays, in vivo studies, diagnostic kits, biotherapeutics, crystallography, cryo-EM and more.
Bioscience
Our in-depth knowledge of target biology, therapeutic area expertise and experience of working collaboratively at each stage of the drug discovery pipeline, supported by a team of over 145 scientists, allows the efficient design and implementation of tailored high-quality assays, which help to accelerate your drug discovery programs.
Chemistry
From design to clinic, Sygnature Discovery’s global chemistry team, with the expertise of over 400 scientists, partners with you to deliver molecules that matter by overcoming complexity, optimizing molecular properties, and accelerating discovery. Our dedicated project leaders and chemists work alongside you, co-designing strategies and guiding decisions.
Drug Metabolism and Pharmacokinetics (DMPK)
At Sygnature Discovery, our integrated in vitro and in vivo DMPK platforms, supported by a team of over 55 scientists, provide mechanistic insight and predictive data that support rational design and informed decision-making, from hit identification through to candidate nomination.
Form and Formulation
From candidate selection to clinic, we partner with you to design smart, scalable formulations built on solid-state insight, multidisciplinary expertise, and a shared commitment to scientific success.
in vivo Pharmacology
Bridging the gap between scientific innovation and patient impact, we deliver high-quality, clinically relevant in vivo data that drives faster, smarter decisions through tailored study designs, advanced technologies, and close collaboration across disciplines. Backed by the expertise of over 55 scientists, we help improve project outcomes and maximize clinical relevance.
Our Approach
Drug discovery is evolving, and so are the challenges. As global health demands rise, the need for smarter, faster, and more connected science has never been greater. Yet too often, progress is slowed by disconnection between disciplines and data.
At Sygnature Discovery, our aim is to reshape how drug discovery is delivered. Through flexible services and integrated expertise, we enable innovation at every stage. With AI and automation embedded across our workflows, we help you move faster and make confident decisions, delivering results with confidence and integrity.
Whether we’re supporting you through the entire process or just a part of it, our goal isn’t simply to move you to the next stage, it’s to lay the foundations for a successfully marketed drug.
Why Choose Sygnature?
Choosing Sygnature Discovery means partnering with over 700 talented scientists from 50 countries, all focused on your priorities. With no internal drug programs, our sole focus is your success, ensuring total confidentiality and dedicated expertise.
Our co-located teams across the UK and North America collaborate to deliver data-driven, transparent, and rigorous science powered by AI and grounded in integrity. With 60+ candidates advanced since 2011 and many repeat customers, we’re trusted by partners worldwide to deliver excellence, whether for a single study or a strategic program.
Case Studies
Trusted by customers worldwide
Our customers tell us that we act as an extension of their team and provide high quality expertise at every stage of the drug discovery process. Whether we’re supporting you through the entire process, or just a part of it, our goal isn’t simply to move you to the next stage it’s to lay the foundations for a successfully marketed drug.
From Lead to Pre-Candidate Nomination in 18 Months
Progressing from lead to pre candidate nomination in less than half the industry standard timeline, this program shows how connected scientific teams and real time insight can accelerate complex discovery.
Sitryx: Empowering New Ideas
Many intriguing drug discovery programmes begin life at start-up biotech companies. Yet at the outset, these new organisations rarely have the resources or laboratory set-up immediately available to turn their ground-breaking ideas into a new medicine.
Rapid creation of ideas using generative AI (GenAI) with Iktos Makya
Leading generative artificial intelligence (GenAI) algorithms for de novo design are being used routinely within our medicinal chemistry programmes to enable rapid idea generation to address project objectives.
Corcept Therapeutics: Integrated Drug Discovery Collaboration
Corcept Therapeutics, located in Menlo Park, CA, is a leader in the discovery and development of drugs that regulate the effects of cortisol.
CellCentric Lead Optimisation Campaign – CCS1477
CellCentric are developing new treatments for cancer based on their understanding of epigenetics.
Fragment-based hit discovery for the epigenetic target, BRD3
Fragment-based drug discovery allows a wide section of chemical space to be interrogated with a relatively small but diverse library of small molecules.
Hit Identification to 3 Compounds in the Clinic and 6 Development Candidates
UK-based small molecule drug discovery company
Focus on identifying novel treatments of inflammatory respiratory diseases, such as COPD
Explore more of Sygnature
Our scientific solutions are applied across every modality, target class and therapeutic area we work in. Browse the full picture:
How we work
Integrated Drug Discovery
Delivering co-located, multidisciplinary drug discovery programs that combine speed, precision, and scientific rigor to advance candidates with confidence.
Target Identification & Validation
Combining AI-driven insights, expert guidance, and rigorous lab validation to select and confirm targets for successful drug discovery.
Hit Identification
Delivering validated, high-quality hits through integrated technologies, strategic insight, and expert collaboration to advance your program with confidence.
Hit to Lead
Transforming promising hits into viable leads through tailored strategies, early risk assessment, and integrated expertise for clinical success.
Lead Optimisation
Transforming early leads into clinical-quality candidates through integrated expertise, rapid decision-making, and optimized strategies for safety, potency, and exposure.
Direct-to-Biology
Embedding Direct‑to‑Biology methodologies into customer programs enables rapid, systematic expansion of SAR. This approach shortens the path to lead optimization and accelerates the delivery of candidate‑quality compounds.
Modalities
Peptides
Transforming complex peptide concepts into next-generation therapies through integrated design, advanced analytics, and collaborative end-to-end discovery expertise.
Antibody Drug Conjugates
Discover more about our wide range capabilities to support ADC projects.
Targeted Protein Degradation
Targeted Protein Degradation (TPD) is an innovative drug discovery approach focused on previously considered ‘undruggable’ proteins. TPD leverages the cell’s ubiquitin-proteasome system to tag these ‘undruggable’ proteins for degradation.
Biologics
Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.
Target classes and therapeutic areas
Ion channels
Comprehensive ion channel assays and bespoke cell lines deliver high-fidelity screening and safety insights, accelerating hit-to-lead and optimization.
GPCRs
End-to-end GPCR expertise combines advanced assays and structural biology to accelerate candidate selection and deliver confident, data-driven decisions.
Target Classes
Comprehensive target class solutions integrate advanced assays, structural biology, and medicinal chemistry to accelerate hit-to-lead and candidate selection.
Oncology
Accelerating oncology drug discovery through integrated expertise, innovative modalities and translational insight to deliver candidates with real clinical impact.
Inflammation & Immunology
Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.
Computer Aided Drug Design
Our Computer Aided Drug Design (CADD) capabilities combine deep scientific expertise with advanced AI, machine learning, and informatics infrastructure to support smarter, faster decision-making across the drug discovery pipeline.
Neuroscience
Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.
Metabolic Disease
Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.