It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.
Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.
Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.
Discover precise insights into brain neurochemistry with Sygnature Discovery's in vivo microdialysis and cOFM services. With over 20 years of expertise, we design bespoke studies that reveal how compounds modulate neurotransmitter systems in health and disease. Using UHPLC/HPLC with electrochemical detection or mass spectrometry, we deliver robust PK/PD data to support confident CNS decision making.
Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.
Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.
Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.
Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.
Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.
Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.
Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.
Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.
Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.
Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.
Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.
Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.
Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.
Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.
Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.
Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.
Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.
Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
From confirming structure and purity to understanding molecular conformation in solution, our specialists deliver clarity that accelerates discovery. Integrated into every stage of our workflow, NMR ensures smarter design, faster decisions, and reliable outcomes.
Our dedicated NMR spectroscopy team combines scientific precision with creative problem-solving.
Using advanced NMR techniques, we provide the structural clarity that underpins chemistry – from routine characterization to bespoke investigations requiring non-standard approaches.
Embedded within project teams, we collaborate across Chemistry, Formulation, Bioscience, Protein Sciences, and Separation Sciences to confirm purity, assess impurities, and validate reaction outcomes in real time. Walk-up access and streamlined workflows guarantee fast turnaround for internal scientists, while we also support standalone fee-for service projects across diverse sectors.
NMR Spectroscopy Expertise
Our dedicated NMR spectroscopy team combines scientific precision with creative problem-solving. Using advanced small molecule techniques, we provide the structural clarity that underpins structural assignment chemistry- from routine characterization to bespoke investigations requiring non-standard approaches.
Expertise That Builds Confidence
Our NMR specialists bring deep expertise in structure elucidation and conformational analysis. They work alongside our chemistry teams to confirm region and stereochemistry, verify purity, assess salt stoichiometry, and identify unexpected reaction products. Advanced techniques and decades of experience provide the assurance needed to move projects forward.
Efficient, Integrated, and Accessible
NMR is embedded into our daily chemistry workflow. Walk-up instruments and streamlined processes enable rapid data acquisition and analysis, minimizing delays. By integrating NMR data directly into our synthetic and analytical workflows, we deliver real-time structural insight that drives design, synthesis, and optimization.
Dedicated Support and Fee-for-Service
We also provide bespoke NMR studies tailored to the need of each project. From structure confirmation and impurity profiling to complex conformational studies, we tailor solutions you need. Working alongside our Separation Sciences team, we ensure every compound is verified, pure, and ready for the next stage.
Accessible and Collaborative
Our specialists resolve complex structural challenges, from regio and stereochemistry to conformational dynamics, for small molecules, macrocycles, PROTACs, and more.
Integration Across Discovery
Close collaboration with chemistry and formulation teams ensures seamless communication and scientific alignment. In-house high-field NMR capability, supported by off-site ultra-high-sensitivity instruments, provides flexibility and uncompromising data quality.
Connected
For biologically focused programs, explore our BioNMR capabilities, where the same rigor supports protein structure and interaction studies.
Why Choose Sygnature Discovery for NMR Support?
Technology That Drives Understanding
Our NMR platform combines precision and flexibility across a wide range of analytical needs. Automated high-field spectrometers deliver high-quality data for confident structural assignments. When ultra-high sensitivity or specialized equipment is required, we access trusted external facilities without delay.
Integration That Accelerates Discovery
Our NMR specialists work side by side with project teams to provide rapid, reliable feedback on purity, identity, and structural integrity. This integrated approach keeps programs moving smoothly and decisions data driven.
Collaboration That Expands Capability
Chemists have direct walk-up access for routine analysis, while our expert spectroscopists handle complex or bespoke requests always ready to troubleshoot, design, or adapt experiments. For biological structure studies, our complementary BioNMR expertise connects small-molecule insight to protein-level understanding.
Chiral pooling enables efficient screening, but data analysis remains a bottleneck.
This poster presents a YOLO-based machine learning workflow that automates chromatographic peak detections, transforming hours of manual analysis into minutes.
Corcept Therapeutics, Menlo Park, CA: Leading cortisol regulation research, targeting Cushing’s syndrome & cancers.
Case Studies
BioscienceChemistryDMPKin vivo Pharmacology…
Related Capabilities
We bring together a dynamic blend of new talent and experiences pharmaceutical industry experts from around the world, delivering excellence across each stage of discovery.
Integrated purification and analytical solutions using advanced SFC and HPLC delivering high-purity compounds from milligram to kilogram scale with confidence.
Integrated solid form and formulation strategies reduce risk, improve stability and solubility, and accelerate progression from candidate selection to clinic.
Tailored bioscience solutions combining advanced technologies and collaborative expertise to design robust assays and accelerate confident drug discovery decisions.
Main home page for the Protein Science and Structural Biology Department. We take time to understand your target and the ultimate aims of the project and tailor our approach accordingly.
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