It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.
Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.
Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.
Discover precise insights into brain neurochemistry with Sygnature Discovery's in vivo microdialysis and cOFM services. With over 20 years of expertise, we design bespoke studies that reveal how compounds modulate neurotransmitter systems in health and disease. Using UHPLC/HPLC with electrochemical detection or mass spectrometry, we deliver robust PK/PD data to support confident CNS decision making.
Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.
Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.
Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.
Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.
Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.
Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.
Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.
Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.
Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.
Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.
Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.
Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.
Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.
Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.
Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.
Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.
Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.
Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
In drug discovery, generating targets is no longer the challenge.
The real question is how to identify the few worth investing months of research and significant resources to pursue.
Hear expert perspectives on how AI, pathway analysis and scientific expertise are shaping modern target identification.
While others focus on a conventional and well trodden ADC development pathway, Allan Jordan (VP, Oncology Drug Discovery) and Josh Greally (ADC Lead) discuss new approaches. This includes a focus on payload optimisation to enhance a drug’s efficacy and selectivity, thereby maximizing its therapeutic benefit. Better performing end products lead to better patient outcomes.
While others focus on a conventional and well trodden ADC development pathway, Allan Jordan (VP, Oncology Drug Discovery) and Josh Greally (ADC Lead) discuss new approaches. This includes a focus on payload optimisation to enhance a drug’s efficacy and selectivity, thereby maximizing its therapeutic benefit. Better performing end products lead to better patient outcomes.
While others focus on a conventional and well trodden ADC development pathway, Allan Jordan (VP, Oncology Drug Discovery) and Josh Greally (ADC Lead) discuss new approaches. This includes a focus on payload optimisation to enhance a drug’s efficacy and selectivity, thereby maximizing its therapeutic benefit. Better performing end products lead to better patient outcomes.
While others focus on a conventional and well trodden ADC development pathway, Allan Jordan (VP, Oncology Drug Discovery) and Josh Greally (ADC Lead) discuss new approaches. This includes a focus on payload optimisation to enhance a drug’s efficacy and selectivity, thereby maximizing its therapeutic benefit. Better performing end products lead to better patient outcomes.
While others focus on a conventional and well trodden ADC development pathway, Allan Jordan (VP, Oncology Drug Discovery) and Josh Greally (ADC Lead) discuss new approaches. This includes a focus on payload optimisation to enhance a drug’s efficacy and selectivity, thereby maximizing its therapeutic benefit. Better performing end products lead to better patient outcomes.
#MitochonriaUnlocked is a five-part video series from Dr. Tatiana Rosenstock, a neuroscientist at Sygnature Discovery. Across five short episodes, Tatiana shares real-world mitochondrial data and practical guidance to help decision-makers in the CNS disease space understand how, and why, mitochondrial health is becoming central to drug discovery.
#MitochonriaUnlocked is a five-part video series from Dr. Tatiana Rosenstock, a neuroscientist at Sygnature Discovery. Across five short episodes, Tatiana shares real-world mitochondrial data and practical guidance to help decision-makers in the CNS disease space understand how, and why, mitochondrial health is becoming central to drug discovery.
#MitochonriaUnlocked is a five-part video series from Dr. Tatiana Rosenstock, a neuroscientist at Sygnature Discovery. Across five short episodes, Tatiana shares real-world mitochondrial data and practical guidance to help decision-makers in the CNS disease space understand how, and why, mitochondrial health is becoming central to drug discovery.
#MitochonriaUnlocked is a five-part video series from Dr. Tatiana Rosenstock, a neuroscientist at Sygnature Discovery. Across five short episodes, Tatiana shares real-world mitochondrial data and practical guidance to help decision-makers in the CNS disease space understand how, and why, mitochondrial health is becoming central to drug discovery.
#MitochonriaUnlocked is a five-part video series from Dr. Tatiana Rosenstock, a neuroscientist at Sygnature Discovery. Across five short episodes, Tatiana shares real-world mitochondrial data and practical guidance to help decision-makers in the CNS disease space understand how, and why, mitochondrial health is becoming central to drug discovery.
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Peak Proteins, NuChem Sciences, and SB Drug Discovery have now fully integrated with Sygnature Discovery.
