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  • Integrated Drug Discovery

    Integrated Drug Discovery

    Overview

    We deliver truly integrated drug discovery programs. Our co-located teams accelerate compounds from target ID to candidate.

  • Target Identification & Validation

    Target Identification & Validation

    It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.

  • Hit Identification

    Hit Identification

    Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.

  • Hit-to-Lead

    Hit-to-Lead

    High-quality hits with early proof of concept are de-risked and profiled, ready to accelerate your program towards lead optimization.

  • Lead Optimization

    Lead Optimization

    Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.

Featured Resources

  • Modalities

    Modalities

    Overview

    Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.

  • Small Molecules

    Small Molecules

    Expert small molecule discovery from target ID to scale-up, delivering candidates designed for success and market impact.

  • Peptides

    Peptides

    Transforming complex peptide concepts into next-generation therapies through integrated design, advanced analytics, and collaborative end-to-end discovery expertise.

  • Targeted protein degradation

    Targeted protein degradation

    Leveraging induced proximity and CHARMED technology to rapidly design, test, and optimize degraders for previously ‘undruggable’ targets.

  • ADCs

    ADCs

    Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.

  • Biologics

    Biologics

    Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.

Featured Resources

  • Therapeutic Areas

    Therapeutic Areas

    Overview

    Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.

  • Oncology and Immuno-Oncology

    Oncology and Immuno-Oncology

    Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.

  • Inflammation and Immunology

    Inflammation and Immunology

    Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.

  • Neuroscience

    Neuroscience

    Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.

  • Metabolic Diseases

    Metabolic Diseases

    Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.

Featured Resources

  • CellCentric Lead Optimization Campaign - CCS1477

    CellCentric Lead Optimization Campaign - CCS1477

    Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesized and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.

    Case study
  • About Sygnature

    About Sygnature

    At Sygnature Discovery, we deliver world-leading drug discovery solutions to accelerate your compound from idea to clinic.

  • Meet our Team

    Meet our Team

    Our leadership team brings diverse experience and insight, driving collaboration and innovation across drug discovery.

  • Careers

    Careers

    Explore careers at Sygnature Discovery and join a global team committed to science, collaboration, and integrity.

Search Results

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Webinars & Podcasts
AI Meets Expertise: A hybrid Workflow For Modern Target ID | QIAGEN & Sygnature
In drug discovery, generating targets is no longer the challenge. The real question is how to identify the few worth investing months of research and significant resources to pursue. Hear expert perspectives on how AI, pathway analysis and scientific expertise are shaping modern target identification.
Blog
How to choose the right membrane protein mimetic for your research
What are the considerations when deciding upon which option is best to present a target…
Case Studies
Form and Formulation to the rescue
In this short case study, we present how our legendary Form & Formulation (F&F) team…
Case Studies
Moving from a pre-clinical to a clinical API – A different formulation needed
Projects often have different priorities such as budget constraints,…
Case Studies
Delivering Fit-for-Purpose Interleukin for Structural and Functional Studies
Advancing Interleukin Research Through Tailored Protein Production Interleukins (ILs) are a family of cytokines…
Blog
Delivering preclinical data for combined radiotherapy and immunotherapy strategies in oncology
Using our Xstrahl CIX3 cabinet irradiator, we have established…
Blog
Membrane protein drug target? Choose the right research partner
The challenges in pursuing a membrane protein as a drug target Membrane proteins, such…
Blog
The Power of Three: A Route to Smarter Drug Discovery
Discipline Integration: Getting to the Root of a Drug Discovery Issue Challenges in drug…
Blog
Why Impurity Characterization is Critical for Drug Development
The appearance of an unidentified impurity during pharmaceutical development can trigger a cascade of…
Blog
James McAfee Industrial placement student
It has been our pleasure to have James McAfee from Queens University Belfast, working with…
Blog
From Imperial College London to AI-Driven Drug Discovery: My Placement Experience at Sygnature Discovery
Over the past 12 months, Thomas Burke, an MSci Chemistry student from Imperial College…
Case Studies
Generating a PXR Crystal Structure
At Sygnature Discovery, we thrive on solving complex protein challenges—and our recent success in solving…
Blog
Beyond Cell Line Generation: Delivering Cellular Models Designed for Drug Discovery
Cell-based assays play a critical role in modern drug discovery, providing researchers with the…
Case Studies
Early Solid Form Assessment Supports Candidate Selection for STORM Therapeutics’ DHX9 Inhibitor Program
How did Sygnature Discovery’s Form & Formulation team help de-risk two lead candidates using only…
Blog
Supporting Kᵥ7 Drug Discovery: Spotlight Kᵥ7.2/7.3
Why Kv7.2/7.3 Matters The KV7.2/7.3 (KCNQ2/KCNQ3) channel complex plays a critical role in regulating…
Case Studies
Development of a Multimodal Assay System for GDF15/GFRAL Drug Discovery
Transforming Receptor Biology into a Screening-Ready Discovery Platform Successful drug discovery begins with a…
Blog
A Beginner’s Guide to Protein Crystallization and X-ray Data Processing
From Protein Crystal to Three-Dimensional Structure The ability to determine and visualize the atomic…
Blog
Recombinant Factor C vs LAL: A More Sustainable Approach to Endotoxin Testing
Advancing Endotoxin Detection Through Recombinant Factor C Technology Innovative approaches that improve outcomes and…
Blog
When Is Protein Refolding the Right Strategy?
Producing sufficient quantities of active, high-quality protein remains one of the most common challenges…
Blog
Unlocking Protein Insights with NMR Spectroscopy
Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful techniques available for…
Blog
Crystal Soaking and Co-Crystallization: Two Routes to Protein-Ligand Complexes
X-ray crystallography is frequently used during drug discovery to determine…
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