Technical Notes

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CYP Reaction Phenotyping
CYP Reaction Phenotyping
About the Assay The CYP450 Reaction Phenotyping (RePh) assay determines which human CYP450 isoforms are…
Technical Notes DMPK drug-drug interactions
CYP Inhibition | Kinact/KI
CYP Inhibition | Kinact/KI
About the Assay The CYP3A4 (Midazolam) kinact/KI assay is designed to quantify the time-dependent inhibition…
Technical Notes DMPK drug-drug interactions
CYP Inhibition | IC50 Shift
CYP Inhibition | IC50 Shift
About the Assay The IC50 Shift assay is designed to identify and characterise time‑dependent inhibition…
Technical Notes DMPK drug-drug interactions
CYP Inhibition
CYP Inhibition
About the Assay The CYP Inhibition assay evaluates reversible inhibition of seven major human CYP450…
Technical Notes DMPK drug-drug interactions
CYP Induction
CYP Induction
About the Assay Sygnature Discovery’s CYP Induction assay provides a robust in vitro platform for…
Technical Notes DMPK drug-drug interactions
Blood Plasma Partitioning
Blood Plasma Partitioning
About the Assay Sygnature Discovery’s Blood Plasma Partitioning (BPP) assay quantifies how test compounds distribute…
Technical Notes DMPK Tissue binding
Plasma Protein Binding
Plasma Protein Binding
About the Assay Sygnature Discovery’s Plasma Protein Binding (PPB) assay evaluates the extent to which…
Technical Notes DMPK Tissue binding
PAMPA Permeability
PAMPA Permeability
About the Assay Parallel artificial membrane permeability assay (PAMPA) is an in vitro method to…
Technical Notes DMPK Permeability
MDCKII-BCRP
MDCKII-BCRP
About the Assay The MDCKII–BCRP (Madin–Darby canine kidney II) is a canine epithelial cell line…
Technical Notes DMPK Permeability
MDCKII-MDR1
MDCKII-MDR1
About the Assay The MDCKII–MDR1 (Madin–Darby canine kidney II) is a canine epithelial cell line…
Technical Notes DMPK Permeability
Caco-2 Permeability
Caco-2 Permeability
About the Assay The Caco-2 cell line is derived from human colorectal adenocarcinoma. During extended…
Technical Notes DMPK Permeability
Hepatocyte Stability
Hepatocyte Stability
About the Assay Sygnature Discovery’s hepatocyte metabolic stability assay provides a comprehensive in vitro system…
Technical Notes chemical & metabolic stability DMPK
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