Case Studies

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CellCentric Lead Optimisation Campaign – CCS1477
CellCentric Lead Optimisation Campaign – CCS1477
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
Case Studies
Corcept Therapeutics: Integrated Drug Discovery Collaboration
Corcept Therapeutics: Integrated Drug Discovery Collaboration
Corcept Therapeutics, Menlo Park, CA: Leading cortisol regulation research, targeting Cushing’s syndrome & cancers.
Case Studies
Sitryx: Empowering New Ideas
Sitryx: Empowering New Ideas
Many intriguing drug discovery programmes begin life at start-up biotech companies. Yet at the outset, these new organisations rarely have the resources or laboratory set-up immediately available to turn their ground-breaking ideas into a new medicine. This is where collaborations with expert CROs like Sygnature Discovery can accelerate a drug discovery project towards the clinic.
Case Studies
Fragment Screening by Crystallography: An Alternative to High Throughput Screening
Fragment Screening by Crystallography: An Alternative to High Throughput Screening
In this Case Study Helen Gingell and Thirumalai Ulaganathan give an introduction to Fragment based drug discovery (FBDD) with…
Case Studies
Separating Phosphorylation States of a Kinase Using Ion Exchange Chromatography
Separating Phosphorylation States of a Kinase Using Ion Exchange Chromatography
In this case study we present our ability to express, phosphorylate and separate the native…
Case Studies
PepT1 Transporter Assays
PepT1 Transporter Assays
High-throughput, label-free functional profiling with SSME technology The human peptide transporter 1 (hPepT1 / SLC15A1)…
Case Studies
Functional and Pharmacological Profiling of Kv1.x Ion Channels
Functional and Pharmacological Profiling of Kv1.x Ion Channels
Sygnature Discovery offers a fully validated panel of electrophysiology assays spanning the KV1.x subfamily. Using…
Case Studies
GPCR Assay Optimization with Chimeric G Proteins
GPCR Assay Optimization with Chimeric G Proteins
GPCR assay optimization using chimeric G proteins enables improved signalling control and enhanced assay performance.
Case Studies
GDF15-GFRAL Screening & Assay Development
GDF15-GFRAL Screening & Assay Development
GDF15-GFRAL screening tools developed by Sygnature Discovery support the creation of multimodal assay systems for…
Case Studies
Cereblon Crystallography with CRBN-midi: Accelerating Molecular Glue and PROTAC Discovery
Cereblon Crystallography with CRBN-midi: Accelerating Molecular Glue and PROTAC Discovery
Our latest achievement: the successful expression, purification, and crystallization of Cereblon-midi (CRBN-midi) reinforces Sygnature Discovery’s…
Case Studies
5-HT2A Receptor Screening for Psychedelics
5-HT2A Receptor Screening for Psychedelics
5-HT2A receptor screening at Sygnature Discovery enables comparison of hallucinogenic and non-hallucinogeneic psychedelic compounds using…
Case Studies
GIP Receptor Screening & Custom Assays
GIP Receptor Screening & Custom Assays
GIP receptor screening tools developed at Sygnature Discovery enable tailored assay development and functional characterization…
Case Studies
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