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STORM Therapeutics: From Lead to Pre-Candidate Nomination in 18 Months
STORM Therapeutics: From Lead to Pre-Candidate Nomination in 18 Months
Case study
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Sygnature améliore les capacités de Western Blot grâce à l’instrument innovant Simple Western™ Jess. Sygnature…
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Synnature Discovery a le plaisir d’annoncer sa nomination comme finaliste dans la catégorie « Entreprise de…
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Sygnature accélère le processus de découverte de médicaments de ses clients grâce à une meilleure…
Journal Papers
Jonathan Welti, Adam Sharp, Nigel Brooks, Wei Yuan, Christopher McNair, Saswati N Chand, Abhijit Pal,…
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Sygnature Discovery est ravie d’annoncer qu’elle a été nommée Entreprise de l’année lors des Bionow…
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Sygnature Discovery est ravie d’annoncer qu’elle a été nommée Entreprise de l’année lors des Bionow…
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Sygnature s’est associée à Altasciences , une CRO/CDMO basée aux États-Unis et au Canada…
Technical Notes
Learn about the impact of drug binding to red blood cells (RBC) and plasma proteins on pharmacokinetics. Discover how RBC binding can affect drug concentration, pharmacological action, and potential toxicity. Understand the importance of early assessment during drug discovery.
Technical Notes
Drug Metabolism Insights: Explore Metabolite Profiling with Sygnature Discovery. Discover how liver metabolism influences drug clearance, and how Sygnature's specialized assays, utilizing hepatocytes, microsomes, and more, can guide your drug discovery project. Predict in vivo hepatic clearance, identify key metabolic pathways, and optimise administration strategies for enhanced therapeutic outcomes.
Technical Notes
Enhance drug efficacy with Reaction Phenotyping using efficient Bactosomes. Predict interactions & optimise metabolism variability.
Technical Notes
Discover the importance of aqueous solubility in drug discovery and development. Overcome low solubility obstacles with our kinetic and thermodynamic solubility assays. Improve drug absorption and formulation. Explore our DMPK/ADME capabilities now!
Technical Notes
Uncover CYP induction's impact on drug interactions & metabolism. Stay FDA-compliant with CYP1A2, CYP2B6, & CYP3A4 investigations.
Technical Notes
Discover precise cytotoxicity testing with Sygnature's Cell Viability assay. Efficient, innovative, and informed drug safety assessment.
Technical Notes
Explore In Vivo Pharmacokinetic (PK) Studies: Learn about drug absorption, distribution, metabolism, and elimination (ADME). Discover the key parameters - AUC, Cmax, t½, Vss, and clearance - in early-stage drug development. Uncover insights into oral bioavailability and first-pass hepatic elimination. Enhance your understanding of PK through detailed ADME analysis and renal/biliary clearance studies.
Technical Notes
Explore our ready-to-use Dietary-Induced Obese (DIO) mouse and rat models, perfect for assessing weight loss interventions and testing novel treatments. Our DIO mouse model boasts stable weight, significant adiposity, insulin resistance, lipid deposition, and elevated plasma lipids. Experience proven predictive validity in a 4-week study, showcasing the effectiveness of semaglutide. Additionally, our DIO rat model, replicating a calorie-dense Western diet, offers excellent predictive validity with on-demand production in just 16 weeks.
Technical Notes
Explore our rapid model of glucocorticoid-induced insulin resistance, ideal for testing antidiabetic potential of new drugs. Witness the inhibitory effects of mifepristone and CORT125134 on insulin resistance and hyperglycaemia in rats.
Technical Notes
Explore our genetic models of insulin resistance and type 2 diabetes. Our expertise lies in working with animal models predisposed to these conditions, such as ob/ob mice, db/db mice, and Zucker fatty rats. Discover how liraglutide, a clinically approved treatment, mitigates the progression of diabetes in the db/db mouse model. Our standard readouts include glucose tolerance tests and pancreatic insulin quantification. Uncover insights into therapeutic interventions and better understand diabetes-related phenotypes.
Technical Notes
We have developed a robust and reproducible model of diabetes that combines exposure to a…
Technical Notes
Hypophagic potential: Acute Feeding Studies with novel drugs in mice and rats. Rapid assessment, various routes, up to 7-day evaluation. Discover ED50 values & pharmacokinetics. Advance drug development
Technical Notes
The mechanisms underlying the reduction in body weight produced by novel anti-obesity drugs should always…
Technical Notes
Explore body composition analysis for weight loss assessment in mice, differentiating fat loss from harmful water and protein reduction. Methods include DEXA and gold-standard techniques for valuable insights into interventions and drug effects.
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