Flexing High-Throughput Power: Tipless Dispensing with the FlexDrop

Advances in drug discovery continue to drive the need for faster, more flexible, and more resource-efficient screening workflows. Digital dispensing technologies offer a compelling alternative to traditional liquid handling approaches by reducing reagent consumption, simplifying assay setup, and enabling highly precise droplet placement.

In this poster, Sygnature Discovery scientists evaluate the performance of the FlexDrop digital dispenser across a range of assay applications, from kinase inhibitor screening through to cellular dose-response experiments. The data demonstrate how non-contact tipless dispensing can support robust assay performance while significantly reducing consumable requirements.

Download the poster to explore the technology, workflows, and case studies that highlight the potential of FlexDrop for modern screening campaigns.

Digital Dispensing for Modern Drug Discovery

High-throughput screening laboratories face constant pressure to increase productivity while minimizing reagent costs and consumable waste. Traditional liquid handling systems often require significant volumes, disposable tips, or dedicated consumables that can add complexity and cost to screening campaigns.

The FlexDrop platform uses controlled positive air pressure to dispense droplets without physical contact, enabling:

• Precise dispensing from 8 nL to 80 µL
• Compatibility across multiple plate formats, including 96-, 384-, and 1536-well plates
• Support for solvent, aqueous, and viscous liquid classes
• Built-in droplet verification
• Reduced consumable usage compared with conventional liquid handling approaches

Why Flexible Dispensing Matters

Miniaturization and workflow efficiency have become increasingly important across drug discovery programs. Technologies that allow precise low-volume dispensing while maintaining assay robustness can help:

• Reduce screening costs
• Conserve valuable compounds and reagents
• Minimize consumable waste
• Increase experimental flexibility
• Accelerate assay development timelines
• Support sustainable laboratory practices

The case studies presented in this poster demonstrate how digital dispensing technologies can be deployed across both biochemical and cellular applications while maintaining the data quality required for decision-making.

Download the Poster

Download the full conference poster to explore:

• The principles behind FlexDrop non-contact dispensing
• Performance characteristics across multiple liquid classes
• Examples of complex assay pattern generation
• EGFR covalent inhibitor screening workflows
• Cellular assay applications with reduced consumable requirements
• Comparative workflow considerations versus conventional dispensing approaches

This work highlights Sygnature Discovery’s ability to evaluate and implement emerging laboratory technologies that support efficient, high-quality drug discovery workflows. By combining expertise in assay biology, screening sciences, and automation technologies, Sygnature helps partners identify practical solutions that improve productivity while maintaining scientific rigor.