Affiches

Loading…
GRIN Variant Screening Utilizing Automated Electrophysiology
GRIN Variant Screening Utilizing Automated Electrophysiology
GRIN variant screening using automated electrophysiology enables precise assessment of gain- and loss-of-function variants in…
Posters
CLC-1 and CLC-2 Screening Utilizing Automated Electrophysiology
CLC-1 and CLC-2 Screening Utilizing Automated Electrophysiology
CLC-1 and CLC-2 screening using automated electrophysiology enables high-throughput analysis of chloride channel function. Sygnature…
Posters
Revisiting the serotonin binding pose of the 5-HT2A receptor with cryo-EM
Revisiting the serotonin binding pose of the 5-HT2A receptor with cryo-EM
The 5-HT2A receptor is a central serotonin GPCR target in drug discovery, implicated in both…
Posters
Using IVIS bioluminescent imaging to assess in vivo biodistribution of HermesTM nanoparticles
Using IVIS bioluminescent imaging to assess in vivo biodistribution of HermesTM nanoparticles
IVIS bioluminescent imaging allows for non-invasive, longitudinal, detection of in vivo bioluminescent signal. This high…
Posters
Humanising drug discovery with integration of automation workflows
Humanising drug discovery with integration of automation workflows
A current lack of physiologically relevant in vitro cell disease models has led to high…
Posters
Effects of compound targeting different mechanisms on LPS-induced neuroinflammation
Effects of compound targeting different mechanisms on LPS-induced neuroinflammation
Accumulating evidence indicates that neuroinflammation is a common underlying mechanism behind neurodegenerative disorders (e.g. Parkinson’s…
Posters
Cryo-EM for Structurally Enabled Therapeutic Antibody Development Against GPCRs
Cryo-EM for Structurally Enabled Therapeutic Antibody Development Against GPCRs
GPCR-targeting antibodies are increasingly important. Structurally aided maturation of GPCR-antibody interactions can enhance target engagement…
Posters
Radiotherapy sensitises preclinical models to DNA damage response agents
Radiotherapy sensitises preclinical models to DNA damage response agents
Radiotherapy is a key treatment for various cancers often in combination with other therapies. In…
Posters
Applications of FIDA in Protein Science
Applications of FIDA in Protein Science
FIDA (Flow-Induced Dispersion Analysis) allows rapid measurement of protein size in solution and can be…
Posters
Dedicated DMPK for Degraders – a flexible approach for flexible molecules
Dedicated DMPK for Degraders – a flexible approach for flexible molecules
Bifunctional degraders bind and degrade proteins via ubiquitin ligase, despite breaking bRo5 rules. Translating in vitro DMPK data to in vivo performance remains a challenge. At Sygnature Discovery, we provide tailored assays and expertise to support projects involving these compounds. Read more in the poster.
Posters
Load More