Case Studies

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Antibody Drug Conjugate Production Workflow
Antibody Drug Conjugate Production Workflow
In this case study we demonstrate Sygnature Discovery’s ability to provide a complete, end‑to‑end Antibody…
Case Studies
Developing Robust Methods to Determine the Drug Antibody Ratio in ADCs
Developing Robust Methods to Determine the Drug Antibody Ratio in ADCs
In this case study we present how we have evolved and developed a robust analytical…
Case Studies
More Papain, More Problems
More Papain, More Problems
The Challenge Clients sometimes as us to generate Fab and Fc pools from a full-length…
Case Studies
CellCentric Lead Optimisation Campaign – CCS1477
CellCentric Lead Optimisation Campaign – CCS1477
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
Case Studies
Corcept Therapeutics: Integrated Drug Discovery Collaboration
Corcept Therapeutics: Integrated Drug Discovery Collaboration
Corcept Therapeutics, Menlo Park, CA: Leading cortisol regulation research, targeting Cushing’s syndrome & cancers.
Case Studies
Sitryx: Empowering New Ideas
Sitryx: Empowering New Ideas
Many intriguing drug discovery programmes begin life at start-up biotech companies. Yet at the outset, these new organisations rarely have the resources or laboratory set-up immediately available to turn their ground-breaking ideas into a new medicine. This is where collaborations with expert CROs like Sygnature Discovery can accelerate a drug discovery project towards the clinic.
Case Studies
Fragment Screening by Crystallography: An Alternative to High Throughput Screening
Fragment Screening by Crystallography: An Alternative to High Throughput Screening
In this Case Study Helen Gingell and Thirumalai Ulaganathan give an introduction to Fragment based drug discovery (FBDD) with…
Case Studies
Separating Phosphorylation States of a Kinase Using Ion Exchange Chromatography
Separating Phosphorylation States of a Kinase Using Ion Exchange Chromatography
In this case study we present our ability to express, phosphorylate and separate the native…
Case Studies
PepT1 Transporter Assays
PepT1 Transporter Assays
High-throughput, label-free functional profiling with SSME technology The human peptide transporter 1 (hPepT1 / SLC15A1)…
Case Studies
Functional and Pharmacological Profiling of Kv1.x Ion Channels
Functional and Pharmacological Profiling of Kv1.x Ion Channels
Sygnature Discovery offers a fully validated panel of electrophysiology assays spanning the KV1.x subfamily. Using…
Case Studies
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