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  • Integrated Drug Discovery

    Integrated Drug Discovery

    Overview

    We deliver truly integrated drug discovery programs. Our co-located teams accelerate compounds from target ID to candidate.

  • Target Identification & Validation

    Target Identification & Validation

    It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.

  • Hit Identification

    Hit Identification

    Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.

  • Hit-to-Lead

    Hit-to-Lead

    High-quality hits with early proof of concept are de-risked and profiled, ready to accelerate your program towards lead optimization.

  • Lead Optimization

    Lead Optimization

    Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.

Featured Resources

  • Modalities

    Modalities

    Overview

    Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.

  • Small Molecules

    Small Molecules

    Expert small molecule discovery from target ID to scale-up, delivering candidates designed for success and market impact.

  • Peptides

    Peptides

    Transforming complex peptide concepts into next-generation therapies through integrated design, advanced analytics, and collaborative end-to-end discovery expertise.

  • Targeted protein degradation

    Targeted protein degradation

    Leveraging induced proximity and CHARMED technology to rapidly design, test, and optimize degraders for previously ‘undruggable’ targets.

  • ADCs

    ADCs

    Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.

  • Biologics

    Biologics

    Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.

Featured Resources

  • Therapeutic Areas

    Therapeutic Areas

    Overview

    Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.

  • Oncology and Immuno-Oncology

    Oncology and Immuno-Oncology

    Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.

  • Inflammation and Immunology

    Inflammation and Immunology

    Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.

  • Neuroscience

    Neuroscience

    Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.

  • Metabolic Diseases

    Metabolic Diseases

    Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.

Featured Resources

  • CellCentric Lead Optimization Campaign - CCS1477

    CellCentric Lead Optimization Campaign - CCS1477

    Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesized and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.

    Case study
  • About Sygnature

    About Sygnature

    At Sygnature Discovery, we deliver world-leading drug discovery solutions to accelerate your compound from idea to clinic.

  • Meet our Team

    Meet our Team

    Our leadership team brings diverse experience and insight, driving collaboration and innovation across drug discovery.

  • Careers

    Careers

    Explore careers at Sygnature Discovery and join a global team committed to science, collaboration, and integrity.

Search Results

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Case Studies
TRPML1 Electrophysiology
TRPML1 screening using automated electrophysiology provides a robust and efficient platform for ion channel drug discovery. Sygnature Discovery leverages this approach to support compound profiling, mechanism of action studies and lead optimization.
Case Studies
A Multi-Platform Approach to TMEM175 Drug Discovery
TMEM175 screening using a multi-platform approach – including electrophysiology and fluorescence-based assays – enables comprehensive…
Case Studies
BK Channel Screening & β-Subunit Profiling
BK channel screening allows investigation of the functional and pharmacological impact of β-subunit expression using…
Case Studies
GIP Receptor Screening & Custom Assays
GIP receptor screening tools developed at Sygnature Discovery enable tailored assay development and functional characterization…
Case Studies
5-HT2A Receptor Screening for Psychedelics
5-HT2A receptor screening at Sygnature Discovery enables comparison of hallucinogenic and non-hallucinogeneic psychedelic compounds using…
Case Studies
Cereblon Crystallography with CRBN-midi: Accelerating Molecular Glue and PROTAC Discovery
Our latest achievement: the successful expression, purification, and crystallization of Cereblon-midi (CRBN-midi) reinforces Sygnature Discovery’s…
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Electrophysiology
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High Throughput Screening
Case Studies
GDF15-GFRAL Screening & Assay Development
GDF15-GFRAL screening tools developed by Sygnature Discovery support the creation of multimodal assay systems for…
Case Studies
GPCR Assay Optimization with Chimeric G Proteins
GPCR assay optimization using chimeric G proteins enables improved signaling control and enhanced assay performance.
Case Studies
Functional and Pharmacological Profiling of Kv1.x Ion Channels
Sygnature Discovery offers a fully validated panel of electrophysiology assays spanning the KV1.x subfamily. Using…
Case Studies
PepT1 Transporter Assays
High-throughput, label-free functional profiling with SSME technology The human peptide transporter 1 (hPepT1 /…
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Targeted Protein Degradation
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Affinity Selection Mass Spectrometry
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Cell Line Generation and Cell Based Assays [Modal]
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Structural Biology [Modal]
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Hit Identification [Modal]
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DMPK [Modal]
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in vivo Pharmacology [Modal]
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Fragment Based Drug Discovery
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Small Molecules
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