Technical Notes

Loading…
Drug Discrimination
Drug Discrimination
Explore Drug Discrimination: Rat interoceptive cues distinguish CNS drugs. Vital in CNS-active compound assessment for psychoactive effects.
Technical Notes Uncategorized
Self-administration
Self-administration
Intravenous self-administration in rats is an extremely reliable predictor of the risk of abuse by…
Technical Notes Uncategorized
Side Effect Profiling
Side Effect Profiling
We offer a wide range of behavioural and physiological assays that can be used to…
Technical Notes Uncategorized
Receptor Binding
Receptor Binding
Elevate drug discovery with ex vivo receptor binding at Sygnature Discovery. Uncover target engagement & receptor insights for effective compounds.
Technical Notes Uncategorized
Substance Use Disorders: Locomotor Sensitisation
Substance Use Disorders: Locomotor Sensitisation
Explore Locomotor Sensitization in Substance Use Disorders: Our mouse model assesses addiction progression and compound effects.
Technical Notes Uncategorized
Substance Use Disorders: Reinstatement model of drug relapse
Substance Use Disorders: Reinstatement model of drug relapse
To explore therapeutic interventions targeted at reducing the probability of relapse to drug taking following…
Technical Notes Uncategorized
Substance Use Disorders: Withdrawal alleviation
Substance Use Disorders: Withdrawal alleviation
Withdrawal Symptom Relief: Our rat model assesses drug dependence & withdrawal profiles. Explore potential therapeutics now.
Technical Notes Uncategorized
Substance Use Disorders: Cessation of drug self-administration
Substance Use Disorders: Cessation of drug self-administration
To explore potential therapeutic interventions for achieving abstinence, we can utilise the self-administration model in…
Technical Notes Uncategorized
Binge Eating Disorder
Binge Eating Disorder
Sygnature has successfully developed and validated a new rat model of binge-eating disorder. Rats…
Technical Notes Uncategorized
Schizophrenia, Psychosis
Schizophrenia, Psychosis
Advancing Schizophrenia Treatment with potent assays. Breakthrough compounds and hyperactivity reversal. Discover more.
Technical Notes Uncategorized
The ob/ob H-FFC mouse model of NASH and fibrosis
The ob/ob H-FFC mouse model of NASH and fibrosis
Explore NASH & fibrosis in ob/ob H-FFC mouse model. Validate treatments for liver disease, obesity, insulin resistance, and co-morbidities.
Technical Notes Uncategorized
H-FFC mouse model of NASH and fibrosis
H-FFC mouse model of NASH and fibrosis
Non-alcoholic steatohepatitis (NASH) and liver fibrosis are associated with an increased risk of developing hepatocellular…
Technical Notes Uncategorized
Load More