Strategies for Tackling Challenging Membrane Protein Targets

Overcoming Membrane Protein Expression Challenges—Fast

Membrane proteins remain among the most difficult yet valuable drug targets. This poster showcases how Sygnature Discovery uses a rational, tool-enabled pipeline to express and purify these challenging targets, supporting applications from cryo-EM and X-ray crystallography to antibody discovery and biophysical assays.

In 2025, we delivered 100+ cryo-EM-ready samples using a proven workflow combining Boltz2, IMPROvER, FSEC screening, and thermostability profiling.

👉 Download the free poster to learn how our integrated approach accelerates structural biology success.