📣New eBook: Explore the emerging trends shaping next-gen ADC development: Next-Generation Antibody Drug Conjugates

Contact
  • Integrated Drug Discovery

    Integrated Drug Discovery

    Overview

    We deliver truly integrated drug discovery programs. Our co-located teams accelerate compounds from target ID to candidate.

  • Target Identification & Validation

    Target Identification & Validation

    It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.

  • Hit Identification

    Hit Identification

    Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.

  • Hit-to-Lead

    Hit-to-Lead

    High-quality hits with early proof of concept are de-risked and profiled, ready to accelerate your program towards lead optimization.

  • Lead Optimization

    Lead Optimization

    Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.

Featured Resources

  • Modalities

    Modalities

    Overview

    Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.

  • Small Molecules

    Small Molecules

    Expert small molecule discovery from target ID to scale-up, delivering candidates designed for success and market impact.

  • Peptides

    Peptides

    Transforming complex peptide concepts into next-generation therapies through integrated design, advanced analytics, and collaborative end-to-end discovery expertise.

  • Targeted protein degradation

    Targeted protein degradation

    Leveraging induced proximity and CHARMED technology to rapidly design, test, and optimize degraders for previously ‘undruggable’ targets.

  • ADCs

    ADCs

    Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.

  • Biologics

    Biologics

    Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.

Featured Resources

  • Therapeutic Areas

    Therapeutic Areas

    Overview

    Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.

  • Oncology and Immuno-Oncology

    Oncology and Immuno-Oncology

    Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.

  • Inflammation and Immunology

    Inflammation and Immunology

    Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.

  • Neuroscience

    Neuroscience

    Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.

  • Metabolic Diseases

    Metabolic Diseases

    Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.

Featured Resources

  • CellCentric Lead Optimization Campaign - CCS1477

    CellCentric Lead Optimization Campaign - CCS1477

    Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesized and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.

    Case study
  • About Sygnature

    About Sygnature

    At Sygnature Discovery, we deliver world-leading drug discovery solutions to accelerate your compound from idea to clinic.

  • Meet our Team

    Meet our Team

    Our leadership team brings diverse experience and insight, driving collaboration and innovation across drug discovery.

  • Careers

    Careers

    Explore careers at Sygnature Discovery and join a global team committed to science, collaboration, and integrity.

News & Events

Sygnature scientists discuss and share their thoughts about drug discovery, laboratory practice and how to beat some of the world’s worst illnesses.

All Topics
Loading…
Invest in BC
Join us at Invest in BC to engage with investors, industry partners and life sciences innovators, exploring opportunities to advance therapeutic innovation, strategic partnerships and drug…

28 October, 2026

Vancouver, BC, Canada

View the Event
Invest in BC
BMCS Hot Topics: AI in Drug Discovery
Join us for BMCS Hot Topics: AI in Drug Discovery, a virtual event bringing together industry and academic experts to explore the latest applications of AI…

3 November, 2026

Online

View the Event
BMCS Hot Topics: AI in Drug Discovery
Innovation Summit
Join us at the Innovation Summit to explore strategies for translating oncology research into patient impact, with discussions spanning innovation ecosystems, partnerships, licensing, entrepreneurship and emerging…

3 November, 2026

Manchester, UK

View the Event
Innovation Summit
3rd Annual ADC Payload Summit
Join us at the 3rd ADC Payload Summit to explore emerging payload strategies, resistance mechanisms and novel modalities that can improve ADC efficacy, safety and translational…

4 November, 2026

Boston, MA, USA

View the Event
3rd Annual ADC Payload Summit
Protein Structure Determination in Industry
Join us at Protein Structure Determination in Industry to discuss advances in integrated structural biology and protein structure determination, and exchange insights that support target understanding,…

8 November, 2026

Marstrand, Sweden

View the Event
Protein Structure Determination in Industry
BIO-Europe Fall
Join us at BIO-Europe 2026 to explore strategies for advancing biopharmaceutical innovation and gain insights into development and financing landscapes. Can’t attend BIO-Europe? Connect with our team directly Related…

9 November, 2026

Cologne, Germany

View the Event
BIO-Europe Fall
Protein Sciences in Drug Discovery
Join us at ELRIG’s Protein Sciences in Drug Discovery 2026 to explore how advances in protein science, AI-driven design and novel therapeutic modalities are addressing complex…

10 November, 2026

Stevenage, UK

View the Event
Protein Sciences in Drug Discovery
Automated Synthesis Forum
Join us at the Automated Synthesis Forum to explore emerging technologies in synthetic chemistry, exchange practical insights on automation and workflow innovation, and discuss approaches that…

10 November, 2026

Gothenburg, Sweden

View the Event
Automated Synthesis Forum
Neuroscience 2026
Join us at Neuroscience 2026 to explore advances in neuroscience research, translational science and emerging technologies, while engaging with the global scientific community shaping the future…

14 November, 2026

Washington D.C, USA

View the Event
Neuroscience 2026
PEGS Europe
Join us at PEGS Europe 2026 to explore advances in protein and antibody engineering, AI-driven biologics discovery, and emerging therapeutic formats addressing challenging targets across a…

16 November, 2026

Lisbon, Portugal

View the Event
PEGS Europe