Functional and Pharmacological Profiling of Kv1.x Ion Channels

Sygnature Discovery offers a fully validated panel of electrophysiology assays spanning the K_V1.x subfamily. Using automated electrophysiology platforms, each isoform was profiled to define its unique activation and inactivation kinetics, alongside pharmacological assessment using both broad-spectrum and subtype-selective inhibitors. The K_V1.x panel enables detailed analysis of potency, selectivity and mechanism of action, providing a robust platform for compound screening and mechanistic studies.

Kv1 channels play essential roles in regulating neuronal excitability, immune cell function ad cardiac repolarisation. K_V1.3, in particular, has emerged as a target of interest in oncology, autoimmune and metabolic diseases, while other K_V1.x family members have been implicated in neurological and cardiovascular disorders. These findings highlight the value of isoform-resolved assays in supporting ion channel drug discovery across diverse therapeutic areas.

Electrophysiology and pharmacological profiling revealed distinct kinetic signatures and selective compound responses across the K_V1.x subfamily. The full dataset, including current traces, I-V curves, and compound response profiles is available in the downloadable case study.