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  • Integrated Drug Discovery

    Integrated Drug Discovery

    Overview

    We deliver truly integrated drug discovery programs. Our co-located teams accelerate compounds from target ID to candidate.

  • Target Identification & Validation

    Target Identification & Validation

    It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.

  • Hit Identification

    Hit Identification

    Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.

  • Hit-to-Lead

    Hit-to-Lead

    High-quality hits with early proof of concept are de-risked and profiled, ready to accelerate your program towards lead optimization.

  • Lead Optimization

    Lead Optimization

    Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.

Featured Resources

  • Modalities

    Modalities

    Overview

    Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.

  • Small Molecules

    Small Molecules

    Expert small molecule discovery from target ID to scale-up, delivering candidates designed for success and market impact.

  • Peptides

    Peptides

    Transforming complex peptide concepts into next-generation therapies through integrated design, advanced analytics, and collaborative end-to-end discovery expertise.

  • Targeted protein degradation

    Targeted protein degradation

    Leveraging induced proximity and CHARMED technology to rapidly design, test, and optimize degraders for previously ‘undruggable’ targets.

  • ADCs

    ADCs

    Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.

  • Biologics

    Biologics

    Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.

Featured Resources

  • Therapeutic Areas

    Therapeutic Areas

    Overview

    Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.

  • Oncology and Immuno-Oncology

    Oncology and Immuno-Oncology

    Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.

  • Inflammation and Immunology

    Inflammation and Immunology

    Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.

  • Neuroscience

    Neuroscience

    Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.

  • Metabolic Diseases

    Metabolic Diseases

    Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.

Featured Resources

  • CellCentric Lead Optimisation Campaign - CCS1477

    CellCentric Lead Optimisation Campaign - CCS1477

    Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.

    Case study
  • About Sygnature

    About Sygnature

    At Sygnature Discovery, we deliver world-leading drug discovery solutions to accelerate your compound from idea to clinic.

  • Meet our Team

    Meet our Team

    Our leadership team brings diverse experience and insight, driving collaboration and innovation across drug discovery.

  • Careers

    Careers

    Explore careers at Sygnature Discovery and join a global team committed to science, collaboration, and integrity.

Protein and Structure
Get in touch

supporting your research

Every protein expression and purification project at Sygnature Discovery begins with a case-by-case approach. We take time to understand the nuances of your target protein and its intended application, ensuring that every proposal is grounded in literature precedence and shaped by our in-house expertise.

This tailored strategy allows us to align construct design, expression systems, and purification methods with your scientific goals.

Applying our extensive experience, we develop protocols to produce purified proteins for a wide range of applications from biochemical assays and structural biology to diagnostic kits, antigens, and biotherapeutics.

3D visualization of protein structures interacting with a cell membrane, representing protein expression and purification processes for applications in biotherapeutics, diagnostics, and structural biology.

Our Protein Expression & Purification Solutions

Our dedicated cell science team
enables us to support multiple
projects simultaneously. They
work closely with our protein
science team whose primary goal
is to deliver your target proteins
with exceptional quality.

Laboratory gel electrophoresis image representing construct design for optimized protein purification and stability

Construct Design

We invest time upfront in construct design to avoid downstream issues and accelerate timelines. Every decision is made with the end use in mind, optimizing for purification efficiency and protein stability.

Flasks with cell culture media illustrating protein expression in optimized host cell systems for successful purification

Protein Expression

We select the most suitable host cell system whether E. coli, insect, or mammalian, based on the protein target and its application. This ensures optimal expression conditions and sets the foundation for successful purification.

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Electrophoresis gel showing protein purification strategies using affinity tags and tailored protocols.

Protein Purification

Using affinity tags and other features, we design purification strategies that consider the protein’s biophysical properties, post-translational modifications, and any project-specific quality requirements. Our goal is to deliver pure, functional proteins that meet your exact specifications.

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Laboratory setup with analytical instruments for protein characterization and quality assessment

Protein Characterization

We apply a range of analytical techniques to confirm the identity, quantity, and quality of the proteins we produce. This ensures confidence in the material you receive and supports downstream applications with robust data.

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3D visualization of membrane proteins embedded in lipid bilayer, representing specialized purification approaches

Membrane Proteins

Our dedicated membrane protein team specializes in producing and purifying these complex targets. With deep expertise and tailored approaches, we overcome the challenges that typically hinder membrane protein projects.

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3D molecular rendering of antibodies interacting with antigens, illustrating biotherapeutic development and ADC mechanisms

Antibodies & Biotherapeutics

We have extensive experience in generating antibodies and antibody fragments, and in supporting biotherapeutic development. This includes antibody-drug conjugates (ADCs) and other protein-based active pharmaceutical ingredients (APIs), helping you advance novel therapies with confidence.

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Resources

Related Resources

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Steve’s Pymol Cheat Sheet
Steve’s Pymol Cheat Sheet
Protocols
Biological Buffers
Biological Buffers
Protocols
DNA Factsheet
DNA Factsheet
Protocols
Fluorescent Protein Tags
Fluorescent Protein Tags
Protocols
Protease Information
Protease Information
Protocols
Protein Construct Naming Convention
Protein Construct Naming Convention
Protocols

Related Solutions

We bring together a dynamic blend of new talent and experienced pharmaceutical industry experts from a round the world, delivering excellence across every stage of discovery.

Protein & Structure

Protein & Structure

Main home page for the Protein Science and Structural Biology Department. We take time to understand your target and the ultimate aims of the project and tailor our approach accordingly.

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Bioscientist

Bioscience

Tailored bioscience solutions combining advanced technologies and collaborative expertise to design robust assays and accelerate confident drug discovery decisions.

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Protein Charaterisation

Protein Characterization

We provide advanced biophysical techniques for protein identity, quality, and stability. Including mass spectrometry, FIDA, and NMR tailored to your research needs.

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Membrane Proteins

Membrane Proteins

This complex and diverse class of proteins are amongst the most valuable for drug discovery. At Sygnature we have a team of specialists dedicated to the production of these challenging targets. 

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