It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.
Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.
Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.
Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.
Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.
Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.
Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.
Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.
Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.
Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.
Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.
Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.
Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.
Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.
Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.
Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.
Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.
Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.
Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.
Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.
Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
At Sygnature Discovery, we design scalable synthetic routes that keep your program moving forward with clarity, confidence, and speed.
By embedding process chemistry early, we help you avoid rework, reduce risk, and accelerate progression from milligram to kilogram. Our scientists work as an extension of your team, combining strategy, technical precision, and hands-on problem solving to ensure momentum at every stage.
Every route is designed with scale-up and technology transfer in mind, preventing bottlenecks and minimizing risk as your program advances toward manufacture.
From gram-scale exploratory chemistry to multi-kilogram batches, we deliver consistent, dependable processes that support your molecule throughout its journey. Process chemists work inside multidisciplinary discovery teams to future-proof routes, maintain scientific momentum, and ensure early decisions continue to support your goals. Our process chemistry team blends operational scale thinking with scientific creativity. From early lead optimization to preclinical supply, we design robust and reproducible routes that accelerate delivery and reduce downstream risk.
Deep retrosynthetic insight combined with cost, safety, and environmental considerations guides every design decision. At Sygnature Discovery, our strength is turning discovery complexity into chemistry that can scale. We combine precision, experience, and foresight to design processes that move programs forward with confidence.
Key Strengths
Process chemistry is woven through the entire discovery chain, linking seamlessly with synthetic chemistry, separation sciences, and analytical chemistry to ensure continuity from hit to batch. We continually adopt new technologies and methodologies to sho rten cycle times and strengthen robustness, helping programs advance efficiently while staying ready for tech transfer.
Strategic route design
Deep retrosynthetic insight combined with cost, safety and environmental considerations guides every design decision.
Advanced process technologies
Flow chemistry, photochemistry, high pressure systems and state of the art reactors keep us at the forefront of scalable innovation.
Scale-ready infrastructure
Dedicated equipment and reliable supply chains allow us to deliver milligram to kilogram quantities with assurance.
Integrated team mindset
Process chemistry, synthetic chemistry, separation sciences and analytical teams collaborate with one goal: your success.
Why Choose Sygnature Discovery for Process Chemistry Support?
Robustness, scalability, and collaboration matter. Our process chemists bring early insight, cutting-edge tools, and transfer- ready routes that accelerate your path from discovery to batch. With full integration across adjacent disciplines, we help you scale with confidence, manage risk, and move molecules toward the clinic more efficiently.
Why Early Process Chemistry Matters Early-stage synthetic chemistry is designed for exploration. Medicinal chemists rightly…
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Related Solutions
We bring together a dynamic blend of new talent and experienced pharmaceutical industry experts from a round the world, delivering excellence across every stage of discovery.
Integrated solid form and formulation strategies reduce risk, improve stability and solubility, and accelerate progression from candidate selection to clinic.
Creative, scalable synthetic chemistry solutions using modern methodologies and advanced tools, transforming complex challenges into efficient, high-quality outcomes.
Clinically focused medicinal chemistry combining design excellence, AI-driven insight, and collaborative expertise to deliver molecules aligned with your goals.
Integrated purification and analytical solutions using advanced SFC and HPLC delivering high-purity compounds from milligram to kilogram scale with confidence.
