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Effective drug design: insights from DMPK
Effective drug design: insights from DMPK
Modelling and simulation approaches developed under the DMPK umbrella utilising animal in vivo data and…
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Preventing Costly Delays: Accessing Drug Formulation Expertise Early
Preventing Costly Delays: Accessing Drug Formulation Expertise Early
Don’t delay or ignore the solid form aspects and risk the problem of unusual results from studies. Learn more about drug formulation here.
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Human PK Predictions & DMPK in Lead Optimisation
Human PK Predictions & DMPK in Lead Optimisation
Human PK predictions are a key element of any integrated drug discovery process: if…
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De-risking Projects with Form Analysis: Pre-clinical Tox Insights
De-risking Projects with Form Analysis: Pre-clinical Tox Insights
Dr David Pearson, Director of Form and Formulation notes how correct form analysis can improve projects and reflects on a year of the department.
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Neuroplasticity and Neuroinflammation at AD/PD 2023: Sygnature Discovery Insights
Neuroplasticity and Neuroinflammation at AD/PD 2023: Sygnature Discovery Insights
The AD/PD conference is a leading international forum for research in Alzheimer’s and Parkinson’s diseases. Dr Max Mirza shares his thoughts.
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Bifunctional Degrader Drug Discovery: The Power of measuring EPSA
Bifunctional Degrader Drug Discovery: The Power of measuring EPSA
Learn from Dr Phillip MacFaul, Sygnature Discovery’s Principal Scientist in DMPK about measuring EPSA in bifunctional degraders.
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Shaping the Future of Lung Cancer Treatment
Shaping the Future of Lung Cancer Treatment
The 12th of April is a landmark day each year for our VP of Oncology…
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Protein Binders to Degraders: Navigating the Route – Sygnature Discovery
Protein Binders to Degraders: Navigating the Route – Sygnature Discovery
Developing orally bioavailable degraders with CHARMED. De-risk the challenges and speed up early proof of concept.
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Have you considered a PROTAC approach?
Have you considered a PROTAC approach?
Recently, there has been a great deal of interest in the potential of PROTACs…
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