📣From lead to pre-candidate nomination in 18 months. Explore the STORM Therapeutics case study

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  • Integrated Drug Discovery

    Integrated Drug Discovery

    Overview

    We deliver truly integrated drug discovery programs. Our co-located teams accelerate compounds from target ID to candidate.

  • Target Identification & Validation

    Target Identification & Validation

    It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.

  • Hit Identification

    Hit Identification

    Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.

  • Hit-to-Lead

    Hit-to-Lead

    High-quality hits with early proof of concept are de-risked and profiled, ready to accelerate your program towards lead optimization.

  • Lead Optimization

    Lead Optimization

    Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.

Featured Resources

  • Modalities

    Modalities

    Overview

    Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.

  • Small Molecules

    Small Molecules

    Expert small molecule discovery from target ID to scale-up, delivering candidates designed for success and market impact.

  • Peptides

    Peptides

    Transforming complex peptide concepts into next-generation therapies through integrated design, advanced analytics, and collaborative end-to-end discovery expertise.

  • Targeted protein degradation

    Targeted protein degradation

    Leveraging induced proximity and CHARMED technology to rapidly design, test, and optimize degraders for previously ‘undruggable’ targets.

  • ADCs

    ADCs

    Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.

  • Biologics

    Biologics

    Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.

Featured Resources

  • Therapeutic Areas

    Therapeutic Areas

    Overview

    Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.

  • Oncology and Immuno-Oncology

    Oncology and Immuno-Oncology

    Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.

  • Inflammation and Immunology

    Inflammation and Immunology

    Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.

  • Neuroscience

    Neuroscience

    Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.

  • Metabolic Diseases

    Metabolic Diseases

    Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.

Featured Resources

  • CellCentric Lead Optimisation Campaign - CCS1477

    CellCentric Lead Optimisation Campaign - CCS1477

    Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.

    Case study
  • About Sygnature

    About Sygnature

    At Sygnature Discovery, we deliver world-leading drug discovery solutions to accelerate your compound from idea to clinic.

  • Meet our Team

    Meet our Team

    Our leadership team brings diverse experience and insight, driving collaboration and innovation across drug discovery.

  • Careers

    Careers

    Explore careers at Sygnature Discovery and join a global team committed to science, collaboration, and integrity.

Scientific Solutions
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supporting your research

We value that effective data management is critical to success. Robust data management transforms how data is perceived and shared, making it an asset for collaboration, integration, and investor confidence. Yet, managing raw data and configuring platforms to meet unique project needs can be complex. Our Dotmatics support can deliver tailored configurations and optimizations, ensure the system works for your unique needs.

With more than a decade of experience managing cloud-hosted databases, Sygnature Discovery has built a reputation for excellence in Dotmatics support from system set up and optimization to guiding basic configurations and fully integrated platforms. Combining industry know-how with data management expertise, we ensure your data works harder for you.

Why Choose an Integrated Data Platform?
No Platform
Sygnature Discovery Dotmatics
Your Dotmatics

Data Storage

Single files, sdf, Excel

Oracle database

Oracle database

Data Access

Local Files

Web interface

Web interface

Data System

Sygnature Dotmatics System

Your Dotmatics System

Data Management

Centralized, standardized, streamlined, integrated

Centralized, standardized, streamlined, integrated

Data Sharing

Email, or file-sharing platform

Securely managed, audited

Securely managed, audited

Data Findability

Not straightforward

Indexed, easy to search based on structure, ID, property, etc.

Indexed, easy to search based on structure, ID, property, etc.

Setting You Up for Success

From day one, we help you transition from standard ‘vanilla’ setups to streamlined, accessible databases that accelerate your research. Our proven track record reflects unmatched knowledge, precision execution, and an unwavering commitment to catalyzing your success.

Key Benefits of Dotmatics Support

Harness Proven Flexibility with Confidence

Dotmatics is a leading informatics platform for drug discovery, adaptable across scientific fields. With Sygnature’s specialist support, you can fully leverage this flexibility without complexity.

Precision Configuration for Every Project

Dotmatics’ power lies in its configurability, but this requires expertise. Our team ensures accurate setup and optimization tailored to your workflows, so your system performs exactly as intended.

Unlock Full Potential and Drive Innovation

Correct configuration transforms Dotmatics into a strategic asset, enabling seamless collaboration, integration with CROs, and enhancing investor confidence. Sygnature helps you realize its full capabilities for success.

Navigating the DMTA Spectrum

Our dedicated Dotmatics team supports every stage of the DMTA cycle. From compound registration to advanced Structure-Activity Relationship (SAR) analysis, we make sure your data flows seamlessly, enabling faster insights and better decisions.

Why Choose Sygnature Discovery

With a wealth of experience behind us, our seasoned experts offer unmatched insights. This collaborative approach means you’re never working with a siloed team; we bring together diverse expertise to deliver comprehensive solutions.

Don’t let valuable data sit idle. Our specialists help you transform it into a strategic asset that drives innovation and accelerates progress. With Sygnature Discovery, your data becomes a catalyst for success.

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Related Research and Resources

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Related Capabilities

We help you design smarter compounds and make faster decisions by combining AI- powered modeling, extensive scientific expertise, and secure, collaborative data access to solve complex challenges and accelerate your drug discovery journey.

Protein Structure Prediction

Protein Structure Prediction

Using advanced AI and proven modelling techniques to predict protein structures with confidence, accelerating structure-based drug design and discovering novel therapeutic
possibilities.

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Protein Ternary Prediction

Protein Ternary Prediction

Helping you design and optimize ternary complexes with precision, combining advanced modeling and collaborative expertise, making previously “undruggable” targets tractable.

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Molecular Dynamic Simulations

Molecular Dynamic Simulations

Utilizing cutting-edge technologies and proprietary software to uncover hidden interactions, predict ligand stability, and make confident design choices that accelerate your drug discovery program.

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Generative AI and Machine Learning

Generative AI and Machine Learning

Combining AI-driven design, bespoke ML models and LLM-powered bioinformatics with hands-on collaboration to help you discover Optimized drug candidates faster.

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Virtual Screening

Virtual Screening

Identifying high-quality hits fast through giga-scale virtual screening, curated libraries, and expert triaging to accelerate drug discovery programs.

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Target Analysis

Target Analysis

From binding sites to druggability, our computational chemistry and protein science teams help you find the right starting points faster, combining structural insight with cutting-edge tools to design compounds that move your project forward with confidence.

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Ligand Based Drug Discovery

Ligand Based Drug Design

Leveraging the properties of known active molecules to rapidly generate and optimize new compounds through ligand-driven insights, AI-powered tools, and collaborative expertise to uncover new chemical space and accelerate discovery.

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Structure-Based Drug Design

Structure Based Drug Design

Helping you design better compounds with greater confidence. Utilizing quantum-level insights and dynamic simulations we predict affinity, guide optimization, and help you prioritize the right candidates faster.

Learn more

FAQs

Leveraging our expertise and commitment to customization, we help you gain a strategic advantage. Focusing on compliance, security, and productivity, we enhance success in pharmaceutical and biotech projects.

Our Computational Sciences and Informatics specialists respond quickly to resolve issues. We integrate Dotmatics with lab instruments, databases, and software systems to keep workflows smooth and efficient, reducing bottlenecks and enhancing overall operational efficiency.

We tailor Dotmatics to your research needs, ensuring alignment with your workflows and objectives. This boosts productivity and improves data accuracy.