It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.
Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.
Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.
Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.
Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.
Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.
Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.
Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.
Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.
Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.
Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.
Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.
Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.
Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.
Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.
Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.
Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.
Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.
Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.
Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.
Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.
Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.
Our integrated workflows ensure consistency from early synthesis to large-scale production. Routine checks of purity, identity, and stability keep separation, analytical, and chemical teams aligned throughout the process.
Every compound is purified, characterized, and ready for the next stage. From analytical screening to large-scale purification, we combine advanced instrumentation with decades of chromatographic experience to deliver clarity, confidence, and continuity.
Smarter separation.
Our separation sciences platform delivers purity from milligram to kilogram.
Separation Science Expertise
We make purification simple, scalable, and reliable. Our expert separation sciences teams provide complete analytical and purification support for chiral and achiral compounds. Using advance SFC and HPLC technologies, we deliver high-purity results from milligram to kilogram quantities ensuring speed, precision, and confidence under one roof.
Purification Without Barriers
Purification should never slow down your program. At Sygnature Discovery, we remove bottlenecks by combining deep technical expertise with tailored methodologies. From high-throughput library purifications to multi-kilogram deliveries, our scientists ensure quality and continuity at every stage of drug discovery.
Advanced Technologies for Reliable Results
Our state-of-the-art facilities feature Supercritical Fluid Chromatography (SFC) and High-Performance Liquid Chromatography (HPLC) platforms for chiral and achiral separations. Integrated analytical instrumentation verifies purity and identity at every step, giving you complete confidence in compound integrity.
Scalable, Integrated, and Efficient
We support projects from early discovery through preclinical supply with rapid turnaround and reproducible results. Our purification capabilities are fully integrated with Analytical Chemistry, High Throughput Chemistry (HTC), and Process Chemistry enabling seamless data flow, informed decisions, and accelerated timelines.
Advanced Technology That Delivers Confidence Our scientists use cutting-edge SFC and HPLC platforms for precise, reproducible purifications. Automated workflows with real-time analytical verification ensure consistent, high quality outputs.
Integration That Eliminates Bottlenecks Separation Sciences is fully integrated with Analytical Chemistry, Synthetic Chemistry, and Process Chemistry. This connectivity removes delays and transforms purification into a strategic enabler for discovery.
Efficiency Through Expertise and Innovation Behind every platform is a team of chromatography experts who combine scientific intuition with data driven precision. Their experience across scales- from micrograms to multi kilograms optimizes recovery, purity, and speed.
Discover how Sygnature Discovery integrates machine learning into HPLC purification, transforming a data-heavy process into a streamlined, automated workflow. This innovation achieves 95% method selection accuracy, saving time and ensuring high-quality compounds for clients.
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Related Capabilities
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Scalable, transfer-ready process chemistry embedded early combining strategic route design and advanced technologies to reduce risk and accelerate progress.
Automated high-throughput chemistry delivering rapid, high-quality compound libraries enabling efficient SAR exploration and faster progression from concept to candidate.
Creative, scalable synthetic chemistry solutions using modern methodologies and advanced tools, transforming complex challenges into efficient, high-quality outcomes.
Clinically focused medicinal chemistry combining design excellence, AI-driven insight, and collaborative expertise to deliver molecules aligned with your goals.
