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  • Integrated Drug Discovery

    Integrated Drug Discovery

    Overview

    We deliver truly integrated drug discovery programs. Our co-located teams accelerate compounds from target ID to candidate.

  • Target Identification & Validation

    Target Identification & Validation

    It’s important to lay strong foundations for successful drug discovery at this first stage of the process. Our integrated target identification and validation platform combines AI with expert insights, and rigorous lab validation to guide targets through robust evaluation, ready for hit discovery.

  • Hit Identification

    Hit Identification

    Validated, high-quality hits, delivered through integrated technologies and expert collaboration, give you a confident starting point for faster drug discovery.

  • Hit-to-Lead

    Hit-to-Lead

    High-quality hits with early proof of concept are de-risked and profiled, ready to accelerate your program towards lead optimization.

  • Lead Optimization

    Lead Optimization

    Turning promising leads into clinical candidates with speed, precision, and the scientific expertise to generate high-quality data and deliver real patient impact.

Featured Resources

  • Modalities

    Modalities

    Overview

    Delivering integrated, modality-agnostic drug discovery to tackle complex biology, accelerate development, and advance innovative therapies with confidence.

  • Small Molecules

    Small Molecules

    Expert small molecule discovery from target ID to scale-up, delivering candidates designed for success and market impact.

  • Peptides

    Peptides

    Transforming complex peptide concepts into next-generation therapies through integrated design, advanced analytics, and collaborative end-to-end discovery expertise.

  • Targeted protein degradation

    Targeted protein degradation

    Leveraging induced proximity and CHARMED technology to rapidly design, test, and optimize degraders for previously ‘undruggable’ targets.

  • ADCs

    ADCs

    Advancing next-generation ADCs through payload-focused design, integrated expertise, and collaborative innovation to deliver safer, more selective therapies.

  • Biologics

    Biologics

    Driving biologics innovation through integrated design, structural biology, and multidisciplinary expertise to accelerate next-generation therapies from concept to clinic.

Featured Resources

  • Therapeutic Areas

    Therapeutic Areas

    Overview

    Combining deep therapeutic expertise with translational insight to design strategies, reduce risk, and accelerate discovery programs toward clinical success.

  • Oncology and Immuno-Oncology

    Oncology and Immuno-Oncology

    Accelerating oncology drug discovery through integrated expertise, innovative modalities, and translational insight to deliver candidates with real clinical impact.

  • Inflammation and Immunology

    Inflammation and Immunology

    Driving immunology and inflammation drug discovery through tailored assays, translational models, and integrated expertise for faster clinical success.

  • Neuroscience

    Neuroscience

    Advancing CNS drug discovery through integrated models, translational biomarkers, and multidisciplinary expertise to overcome complexity and accelerate therapeutic innovation.

  • Metabolic Diseases

    Metabolic Diseases

    Designing and advancing differentiated small-molecule therapies for obesity and diabetes through integrated expertise, mechanistic insight, and translational strategies.

Featured Resources

  • CellCentric Lead Optimisation Campaign - CCS1477

    CellCentric Lead Optimisation Campaign - CCS1477

    Inobrodib, an exciting, first-in-class oral anti-cancer drug in clinical development by CellCentric, was collaboratively designed, synthesised and supported on its pre-clinical journey by an integrated project team at Sygnature Discovery. Inobrodib is now showing promising results in Phase I and II trials for multiple myeloma and other cancer types.

    Case study
  • About Sygnature

    About Sygnature

    At Sygnature Discovery, we deliver world-leading drug discovery solutions to accelerate your compound from idea to clinic.

  • Meet our Team

    Meet our Team

    Our leadership team brings diverse experience and insight, driving collaboration and innovation across drug discovery.

  • Careers

    Careers

    Explore careers at Sygnature Discovery and join a global team committed to science, collaboration, and integrity.

About Us
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Background

About us

Who We Are

Sygnature Discovery is a contract research organisation, providing world-leading drug discovery solutions to accelerate your compound to the clinic.

Get in touch
Drug discovery team collaborating in a meeting room, discussing strategies to progress from hit identification to lead optimization for early-stage development.

OUR ROLE

Sygnature Discovery creates the conditions for exceptional scientific outcomes – for our customers, who bring life-changing medicines to patients, and for our people, who help make this possible.


Here’s what sets us apart: 700+ scientists from over 50 countries, working as one across Europe and North America. No competing internal programs means total commitment and confidentiality. Every project is tailored to customer needs, and brings together multiple disciplines in shared spaces, on demand.


We’re proud of our track record. 60+ advanced candidates, 200+ patents filed, 200+ active projects. Over 90% of our customers choose to stay with us, from biotechs racing to clinic, to pharma companies that need specialised expertise for targeted challenges.


For 20 years, we’ve upheld principles of scientific collaboration and integrity, growing significantly in breadth and scale while staying true to who we are: hands-on problem solvers, dedicated to your success.


Today, we’re reshaping drug discovery by uniting advanced technologies, diverse disciplines and global expertise, making it more connected, efficient and effective.

laboratory team collaborating on integrated drug discovery programs supporting end-to-end drug discovery from target ID to candidate selection.

Our Purpose

To improve patients’ lives by reimagining the drug discovery journey.

multidisciplinary drug discovery team collaborating supporting real-time decision-making and integrated project planning

Our Mission

To create exceptional outcomes for our customers and people through global collaboration, innovation and integrity.

Careers

At Sygnature Discovery, we strive to attract top talent from around the globe, offering diverse career opportunities in drug discovery across multiple scientific disciplines.

We’re looking for individuals who share our passion for advancing drug discovery research. We hire exceptional scientists with the ambition to improve human health and the technical expertise to make it happen. As a Skilled Worker Visa sponsor, we welcome applications from candidates worldwide.

Check out our current vacancies
scientist working

Our Values

Excellence

We commit to leading in our field by continually advancing our capabilities and striving for excellence. We care deeply about the impact of our work and stay grounded in its purpose. We remain accountable and approach every project with a sense of ownership. We celebrate and invest in our people’s growth, they’re what makes our science exceptional.

Collaboration

We unite diverse perspectives across disciplines, locations and roles. We work as an extension of our customers’ teams, sharing knowledge freely to achieve shared success. We build trust through honest communication, listening carefully and delivering on our promises. We treat everyone with inclusivity, humility and respect.


Innovation

We accelerate breakthroughs by pushing the boundaries of innovation. We’re naturally curious, taking calculated risks to spot opportunities others miss. We work at pace towards our goals, but are always prepared to change trajectory. We’re driven by the data and apply it with rigour and precision.

Sygnature has a very strong group of scientists who were willing to go above and beyond expectations to help us deliver a very strong development candidate. Their expertise in all aspects of the drug discovery process is among the best I have seen in the industry and I would definitely work with them again.

Peter Astles

Project Lead and Principle Scientist, STORM Therapeutics

Our Team

More than 70% of Sygnature’s scientists hold a PhD, and many bring extensive pharmaceutical industry experience to every project we undertake. This expertise enables us to collaborate as true scientific partners with our customers, providing meaningful intellectual input and drug discovery know-how to help advance their programs towards the clinic. We act as an extension of your team.

Our approach is built on forming genuine partnerships. That means maintaining clear, open communication at every stage, offering honest insights into project viability, and recommending the best path forward.

Meet our team
scientists reviewing work chemistry