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Efficient fragment library screening at Sygnature Discovery by SPR and MST


Sygnature Discovery engages with clients in a range of integrated drug discovery projects.  Efficient hit finding approaches are critical to the early stages of these programmes.

Fragment screening represents an extremely efficient approach to identifying chemical starting points for a drug discovery programme through its coverage of a wide range of chemical space with a relatively small library of compounds.

Sygnature Discovery’s proprietary fragment library is routinely screened for chemical starting points to support these programmes using two powerful and complementary technological platforms: (1) Surface plasmon resonance (SPR) using the high throughput and sensitive Biacore 8K, and (2) Microscale thermophoresis (MST) using the automated Nanotemper Monolith instrument.

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Dr. Chris Tomlinson – Efficient Fragment Library