Shifting the Spectrum: Identification of Novel Fragment Hits for the VHL-Elongin B/C Complex by Spectral Shift and SPR

Novel Fragment Hits for VHL: Expanding the PROTAC Toolbox

Discover how Sygnature Discovery’s curated fragment library and advanced screening platforms (Biacore 8K+, Dianthus) enable the identification of new VCB-binding fragments—paving the way for more efficient and orally bioavailable PROTACs.

Learn how we applied spectral shift and SPR screening to over 2,000 fragments to uncover untapped chemical space beyond classical VHL ligands.

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