{"id":21557,"date":"2026-11-10T10:31:05","date_gmt":"2026-11-10T10:31:05","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=webinar-and-podcast&#038;p=21557"},"modified":"2026-11-10T11:00:57","modified_gmt":"2026-11-10T11:00:57","slug":"get-it-right-from-the-start-how-to-build-confidence-through-the-hit-discovery-process","status":"publish","type":"webinar-and-podcast","link":"https:\/\/www.sygnaturediscovery.com\/fr\/webinar-and-podcast\/get-it-right-from-the-start-how-to-build-confidence-through-the-hit-discovery-process\/","title":{"rendered":"Get it right from the start \u2013 How to build confidence through the hit discovery process."},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\"><strong>Integrating FIDA\u2122 and Biacore\u2122 SPR for optimal results<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Biophysical discovery depends on confidence in your reagents from the very beginning. When protein quality, stability, and behavior are fully understood early in a campaign, downstream hit identification and characterization become faster, more reliable, and far less prone to costly surprises.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As drug discovery programs increasingly target challenging proteins, novel modalities, and complex biological systems, researchers need workflows that can generate robust data while reducing risk at every stage. But how can you confidently assess reagent quality, troubleshoot difficult assays, and ensure that promising hits are genuinely worth pursuing?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this webinar, experts from <strong>Sygnature Discovery, Fida Biosystems, and Cytiva<\/strong> explore how combining <strong>FIDA\u2122 (Flow Induced Dispersion Analysis)<\/strong> and <strong>Biacore\u2122 SPR<\/strong> creates a powerful hit discovery workflow that helps researchers build confidence from the start. Together, these complementary technologies provide insights into reagent quality, molecular interactions, and hit validation, enabling teams to make better decisions earlier in discovery programs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Drawing on real-world case studies, the discussion will showcase how integrated biophysical approaches can help overcome common challenges, unlock previously difficult targets, and generate the high-quality data needed to advance the most promising molecules.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><a href=\"#watch\">Watch the webinar now.<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:55px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\"><strong>In This Webinar You&rsquo;ll Learn<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-group is-layout-grid wp-container-core-group-is-layout-d895b8b9 wp-block-group-is-layout-grid\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-6a9a932c wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media original shrink-0\"\n         style=\"\">\n            \n                                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"29\" viewBox=\"0 0 29 29\" fill=\"none\" class=\"image-original \">\n<path d=\"M22.7026 15.1325L16.2551 12.75L13.8801 6.2975C13.7394 5.91541 13.485 5.58566 13.151 5.35273C12.8171 5.11981 12.4197 4.99492 12.0126 4.99492C11.6054 4.99492 11.2081 5.11981 10.8741 5.35273C10.5402 5.58566 10.2857 5.91541 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14.0122 9.47758 13.875L12.0051 7.01875L14.5326 13.875C14.5826 14.0107 14.6615 14.134 14.7638 14.2363C14.8661 14.3386 14.9893 14.4175 15.1251 14.4675L21.9863 17L15.1301 19.5275ZM16.0051 4C16.0051 3.73478 16.1104 3.48043 16.298 3.29289C16.4855 3.10536 16.7399 3 17.0051 3H19.0051V1C19.0051 0.734784 19.1104 0.48043 19.298 0.292893C19.4855 0.105357 19.7399 0 20.0051 0C20.2703 0 20.5247 0.105357 20.7122 0.292893C20.8997 0.48043 21.0051 0.734784 21.0051 1V3H23.0051C23.2703 3 23.5247 3.10536 23.7122 3.29289C23.8997 3.48043 24.0051 3.73478 24.0051 4C24.0051 4.26522 23.8997 4.51957 23.7122 4.70711C23.5247 4.89464 23.2703 5 23.0051 5H21.0051V7C21.0051 7.26522 20.8997 7.51957 20.7122 7.70711C20.5247 7.89464 20.2703 8 20.0051 8C19.7399 8 19.4855 7.89464 19.298 7.70711C19.1104 7.51957 19.0051 7.26522 19.0051 7V5H17.0051C16.7399 5 16.4855 4.89464 16.298 4.70711C16.1104 4.51957 16.0051 4.26522 16.0051 4ZM29.0051 10C29.0051 10.2652 28.8997 10.5196 28.7122 10.7071C28.5247 10.8946 28.2703 11 28.0051 11H27.0051V12C27.0051 12.2652 26.8997 12.5196 26.7122 12.7071C26.5247 12.8946 26.2703 13 26.0051 13C25.7399 13 25.4855 12.8946 25.298 12.7071C25.1104 12.5196 25.0051 12.2652 25.0051 12V11H24.0051C23.7399 11 23.4855 10.8946 23.298 10.7071C23.1104 10.5196 23.0051 10.2652 23.0051 10C23.0051 9.73478 23.1104 9.48043 23.298 9.29289C23.4855 9.10536 23.7399 9 24.0051 9H25.0051V8C25.0051 7.73478 25.1104 7.48043 25.298 7.29289C25.4855 7.10536 25.7399 7 26.0051 7C26.2703 7 26.5247 7.10536 26.7122 7.29289C26.8997 7.48043 27.0051 7.73478 27.0051 8V9H28.0051C28.2703 9 28.5247 9.10536 28.7122 9.29289C28.8997 9.48043 29.0051 9.73478 29.0051 10Z\" fill=\"#005DE5\"\/>\n<\/svg>\n\n                \n            <\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-base-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Start with Better Reagents<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-1 wp-block-paragraph\">Why understanding protein quality, stability, and behaviour early can improve confidence throughout the discovery process.<\/p>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-2 wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-6a9a932c wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media original shrink-0\"\n         style=\"\">\n            \n                                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"29\" viewBox=\"0 0 29 29\" fill=\"none\" class=\"image-original \">\n<path d=\"M22.7026 15.1325L16.2551 12.75L13.8801 6.2975C13.7394 5.91541 13.485 5.58566 13.151 5.35273C12.8171 5.11981 12.4197 4.99492 12.0126 4.99492C11.6054 4.99492 11.2081 5.11981 10.8741 5.35273C10.5402 5.58566 10.2857 5.91541 10.1451 6.2975L7.75508 12.75L1.30258 15.125C0.920493 15.2656 0.59074 15.5201 0.357814 15.854C0.124888 16.188 0 16.5853 0 16.9925C0 17.3997 0.124888 17.797 0.357814 18.131C0.59074 18.4649 0.920493 18.7194 1.30258 18.86L7.75508 21.25L10.1301 27.7025C10.2707 28.0846 10.5252 28.4143 10.8591 28.6473C11.1931 28.8802 11.5904 29.0051 11.9976 29.0051C12.4047 29.0051 12.8021 28.8802 13.136 28.6473C13.47 28.4143 13.7244 28.0846 13.8651 27.7025L16.2551 21.25L22.7076 18.875C23.0897 18.7344 23.4194 18.4799 23.6523 18.146C23.8853 17.812 24.0102 17.4147 24.0102 17.0075C24.0102 16.6003 23.8853 16.203 23.6523 15.869C23.4194 15.5351 23.0897 15.2806 22.7076 15.14L22.7026 15.1325ZM15.1301 19.5275C14.9943 19.5775 14.8711 19.6564 14.7688 19.7587C14.6665 19.861 14.5876 19.9843 14.5376 20.12L12.0051 26.9813L9.47758 20.125C9.42764 19.9878 9.34826 19.8633 9.24504 19.76C9.14182 19.6568 9.01725 19.5774 8.88008 19.5275L2.02383 17L8.88008 14.4725C9.01725 14.4226 9.14182 14.3432 9.24504 14.24C9.34826 14.1367 9.42764 14.0122 9.47758 13.875L12.0051 7.01875L14.5326 13.875C14.5826 14.0107 14.6615 14.134 14.7638 14.2363C14.8661 14.3386 14.9893 14.4175 15.1251 14.4675L21.9863 17L15.1301 19.5275ZM16.0051 4C16.0051 3.73478 16.1104 3.48043 16.298 3.29289C16.4855 3.10536 16.7399 3 17.0051 3H19.0051V1C19.0051 0.734784 19.1104 0.48043 19.298 0.292893C19.4855 0.105357 19.7399 0 20.0051 0C20.2703 0 20.5247 0.105357 20.7122 0.292893C20.8997 0.48043 21.0051 0.734784 21.0051 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7C26.2703 7 26.5247 7.10536 26.7122 7.29289C26.8997 7.48043 27.0051 7.73478 27.0051 8V9H28.0051C28.2703 9 28.5247 9.10536 28.7122 9.29289C28.8997 9.48043 29.0051 9.73478 29.0051 10Z\" fill=\"#005DE5\"\/>\n<\/svg>\n\n                \n            <\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-base-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">De-Risk Challenging Targets<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-3 wp-block-paragraph\">How integrated biophysical workflows can support difficult targets, including complex and membrane-associated proteins.<\/p>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-4 wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-6a9a932c wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section x-data=\"PegasusMediaBlock\" \n         class=\"Media original shrink-0\"\n         style=\"\">\n            \n                                    <svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"29\" height=\"29\" viewBox=\"0 0 29 29\" fill=\"none\" class=\"image-original \">\n<path d=\"M22.7026 15.1325L16.2551 12.75L13.8801 6.2975C13.7394 5.91541 13.485 5.58566 13.151 5.35273C12.8171 5.11981 12.4197 4.99492 12.0126 4.99492C11.6054 4.99492 11.2081 5.11981 10.8741 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style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Understand Complex Sensorgrams<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-5 wp-block-paragraph\">Approaches for investigating unexpected binding behaviour and gaining greater confidence in your data.<\/p>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-6 wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group has-ivory-000-background-color has-background is-vertical is-layout-flex wp-container-core-group-is-layout-6a9a932c wp-block-group-is-layout-flex\" style=\"border-radius:24px;min-height:280px;padding-top:var(--wp--preset--spacing--30);padding-right:var(--wp--preset--spacing--30);padding-bottom:var(--wp--preset--spacing--30);padding-left:var(--wp--preset--spacing--30)\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\"><section 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26.7122 7.29289C26.8997 7.48043 27.0051 7.73478 27.0051 8V9H28.0051C28.2703 9 28.5247 9.10536 28.7122 9.29289C28.8997 9.48043 29.0051 9.73478 29.0051 10Z\" fill=\"#005DE5\"\/>\n<\/svg>\n\n                \n            <\/section>\n\n\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" allowchildrentofillwidth=\"\" overflow=\"\" flexwrap=\"\">\n<h3 class=\"wp-block-heading has-text-base-font-size\" style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Generate More Reliable Hits<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-7 wp-block-paragraph\">How combining solution-based and surface-based technologies can strengthen hit validation and prioritization.<\/p>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-8 wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div 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style=\"margin-bottom:var(--wp--preset--spacing--20);font-style:normal;font-weight:500\">Improve Decision-Making Earlier<\/h3>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-9 wp-block-paragraph\">Why reducing uncertainty at the start of a campaign can save valuable time and resources downstream.<\/p>\n\n\n\n<p class=\"has-content-secondary-color has-text-color has-link-color has-text-sm-font-size wp-elements-10 wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div>\n\n\n\n<div style=\"height:55px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\"><strong>Key Discussion Topics<\/strong><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The growing challenge of working with difficult targets and emerging therapeutic modalities<\/li>\n\n\n\n<li>The role of reagent assessment and quality control in successful hit 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