{"id":13277,"date":"2025-04-07T16:47:00","date_gmt":"2025-04-07T16:47:00","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=webinar-and-podcast&#038;p=13277"},"modified":"2026-01-23T17:13:47","modified_gmt":"2026-01-23T17:13:47","slug":"choosing-the-right-payload-what-makes-a-small-molecule-suitable-for-an-adc","status":"publish","type":"webinar-and-podcast","link":"https:\/\/www.sygnaturediscovery.com\/fr\/webinar-and-podcast\/choosing-the-right-payload-what-makes-a-small-molecule-suitable-for-an-adc\/","title":{"rendered":"Choosing the Right Payload: What Makes a Small Molecule Suitable for an ADC"},"content":{"rendered":"\n<p>This episode focuses on the science behind payload selection. Allan and Josh break down the characteristics that make a small molecule \u201cADC ready,\u201d the trade\u2011offs developers must navigate, and why payload optimisation is a critical factor in driving therapeutic performance.<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-2-xl-font-size\" style=\"padding-top:var(--wp--preset--spacing--40)\">About the Authors<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-123a282d wp-block-columns-is-layout-flex\" style=\"padding-bottom:var(--wp--preset--spacing--40)\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"593\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/sygnature-adc-expert-interview-studio.webp\" alt=\"Picture of Allan Jordan, VP of Oncology Drug Discovery at Sygnature Discovery and Joshua Greally, ADC Lead and Business Development Associate for Drug Discovery Services at Sygnature Discovery, filming the podcast style video series: ADC Development for Sygnature's NewPath ADC series\" class=\"wp-image-13275\" srcset=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/sygnature-adc-expert-interview-studio.webp 800w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/sygnature-adc-expert-interview-studio-300x222.webp 300w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/sygnature-adc-expert-interview-studio-768x569.webp 768w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/sygnature-adc-expert-interview-studio-486x360.webp 486w, https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/sygnature-adc-expert-interview-studio-640x474.webp 640w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p style=\"padding-left:var(--wp--preset--spacing--40)\">Allan Jordan is Vice President Oncology Drug Discovery at Sygnature Discovery and Josh Greally is ADC Lead at Sygnature Discovery.<\/p>\n<\/div>\n<\/div>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" \n         class=\"Media object-contain w-full layout h-full\"\n         style=\"\">\n            \n                            \n\n            <div class=\"w-full h-0 relative \" style=\"padding-bottom: 56.25%\">\n            <iframe title=\"ADC Development Series Ep2: Choosing the Right Payload\" src=\"https:\/\/www.youtube.com\/embed\/4Q0WgzbY4Kc?feature=oembed&amp;rel=0&amp;autoplay=&amp;mute=&amp;muted=&amp;loop=&amp;controls=0\" width=\"640\" height=\"360\" loading=\"eager\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" class=\"video-embed w-full h-full absolute-center \" controls=\"0\"  frameborder=\"0\"><\/iframe>\n        <\/div>\n    \n    <div x-ref=\"videoPlaceholder\" class=\"absolute-center w-full !h-full\" @click=\"playVideo()\">\n        \n\n        <div class=\"preview-play-button absolute-center w-full h-full cursor-pointer\" title=\"Play Full Video\" @click=\"videoModalOpen = true\">\n            <button type=\"button\" class=\"absolute absolute-center w-16 h-16 bg-white\/80 rounded-full flex items-center justify-center\">\n                <span class=\"sr-only\">Play Full Video<\/span>\n                <svg width=\"17\" height=\"20\" viewBox=\"0 0 17 20\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <path d=\"M16.5 8.79609C17.1667 9.18099 17.1667 10.1432 16.5 10.5281L1.5 19.1884C0.833335 19.5733 9.70611e-07 19.0922 1.00426e-06 18.3224L1.76136e-06 1.00185C1.79501e-06 0.232054 0.833336 -0.24907 1.5 0.13583L16.5 8.79609Z\" fill=\"#002B46\"\/>\n                <\/svg>\n            <\/button>\n        <\/div>\n    <\/div>\n\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"<p>While others focus on a conventional and well trodden ADC development pathway, Allan Jordan (VP, Oncology Drug Discovery) and Josh Greally (ADC Lead) discuss new approaches. This includes a focus on payload optimisation to enhance a drug\u2019s efficacy and selectivity, thereby maximizing its therapeutic benefit. Better performing end products lead to better patient outcomes.<\/p>\n","protected":false},"featured_media":13278,"template":"","category":[744,686],"resource_tag":[],"class_list":["post-13277","webinar-and-podcast","type-webinar-and-podcast","status-publish","has-post-thumbnail","hentry","category-adcs","category-modalities"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The Right Payload for ADCs: What Makes a Molecule Suitable?<\/title>\n<meta name=\"description\" content=\"Learn what makes a suitable ADC payload, including the factors that influence potency, selectivity, and overall therapeutic performance.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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