{"id":13266,"date":"2024-05-22T11:43:00","date_gmt":"2024-05-22T11:43:00","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=webinar-and-podcast&#038;p=13266"},"modified":"2026-01-23T16:05:17","modified_gmt":"2026-01-23T16:05:17","slug":"measuring-mitochondrial-dynamics-and-biogenesis-in-different-models","status":"publish","type":"webinar-and-podcast","link":"https:\/\/www.sygnaturediscovery.com\/fr\/webinar-and-podcast\/measuring-mitochondrial-dynamics-and-biogenesis-in-different-models\/","title":{"rendered":"Measuring Mitochondrial Dynamics and Biogenesis in Different Models"},"content":{"rendered":"\n<p>Mitochondria constantly move, divide, and adapt all of which can be measured. In Episode 4, Tatiana explores how mitochondrial dynamics and biogenesis are assessed across <em>ex vivo <\/em>and <em>in vivo <\/em>models. She highlights why these measurements matter, particularly for CNS research, where mitochondrial resilience plays a vital role in disease progression. <\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-xl-font-size\" style=\"padding-top:var(--wp--preset--spacing--40)\">About Tatiana<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Tatiana-Rosenstock_Senior-Principal-Scientist_In-Vitro-Neuroscience_Bioscience.webp\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:var(--wp--preset--spacing--40);flex-basis:66.66%\">\n<p>Tatiana Rosenstock has had an exceptional career and has made significant contributions to the field of Neuroscience for 20+ years.&nbsp;Her work has focused on topics such as mitochondrial deregulation, transcription deregulation, and autophagy in neurodegenerative diseases, such as Huntington\u2019s Disease, and Amyotrophic Lateral Sclerosis, and Schizophrenia.&nbsp;&nbsp;<\/p>\n\n\n\n<p>At Sygnature Discovery, Tatiana is a Principal Scientist overseeing various neuroscience-related projects in different sub-areas such as metabolism (mitochondrial function), biomarkers, microglial function and activation, and neuroplasticity. During this period, she has been working with distinct in-vitro models, named&nbsp;iPSC-derived neurons, primary cortical neurons, Alzheimer`s and Parkinson`s disease fibroblasts, neuroblastomas cell lines, tissue and biofluids from transgenics animal models of Alzheimer`s disease.&nbsp;<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\" style=\"padding-top:var(--wp--preset--spacing--40)\">What You&rsquo;ll Learn<\/h2>\n\n\n\n<ul style=\"padding-bottom:var(--wp--preset--spacing--40)\" class=\"wp-block-list\">\n<li>What mitochondrial dynamics and biogenesis can reveal <\/li>\n\n\n\n<li>How these processes differ across model types<\/li>\n\n\n\n<li>Why the dynamic measurements deepen biological understanding<\/li>\n<\/ul>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" \n         class=\"Media object-contain w-full layout h-full\"\n         style=\"\">\n            \n                            \n\n            <div class=\"w-full h-0 relative \" style=\"padding-bottom: 56.25%\">\n            <iframe title=\"#MitochondriaUnlocked_Measuring the dynamics and biogenesis in different models\" src=\"https:\/\/www.youtube.com\/embed\/wIZzWr7vwl0?feature=oembed&amp;rel=0&amp;autoplay=&amp;mute=&amp;muted=&amp;loop=&amp;controls=0\" width=\"640\" height=\"360\" loading=\"eager\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" class=\"video-embed w-full h-full absolute-center \" controls=\"0\"  frameborder=\"0\"><\/iframe>\n        <\/div>\n    \n    <div x-ref=\"videoPlaceholder\" class=\"absolute-center w-full !h-full\" @click=\"playVideo()\">\n        \n\n        <div class=\"preview-play-button absolute-center w-full h-full cursor-pointer\" title=\"Play Full Video\" @click=\"videoModalOpen = true\">\n            <button type=\"button\" class=\"absolute absolute-center w-16 h-16 bg-white\/80 rounded-full flex items-center justify-center\">\n                <span class=\"sr-only\">Play Full Video<\/span>\n                <svg width=\"17\" height=\"20\" viewBox=\"0 0 17 20\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <path d=\"M16.5 8.79609C17.1667 9.18099 17.1667 10.1432 16.5 10.5281L1.5 19.1884C0.833335 19.5733 9.70611e-07 19.0922 1.00426e-06 18.3224L1.76136e-06 1.00185C1.79501e-06 0.232054 0.833336 -0.24907 1.5 0.13583L16.5 8.79609Z\" fill=\"#002B46\"\/>\n                <\/svg>\n            <\/button>\n        <\/div>\n    <\/div>\n\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"<p>#MitochonriaUnlocked is a five-part video series from Dr. Tatiana Rosenstock, a neuroscientist at Sygnature Discovery. Across five short episodes, Tatiana shares real-world mitochondrial data and practical guidance to help decision-makers in the CNS disease space understand how, and why, mitochondrial health is becoming central to drug discovery. <\/p>\n","protected":false},"featured_media":13267,"template":"","category":[753,688],"resource_tag":[],"class_list":["post-13266","webinar-and-podcast","type-webinar-and-podcast","status-publish","has-post-thumbnail","hentry","category-neuroscience","category-therapeutic-areas"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Measuring Mitochondrial Dynamics and Biogenesis<\/title>\n<meta name=\"description\" content=\"Mitochondrial dynamics and biogenesis measured across ex vivo and in vivo models, and deepen understanding in CNS research.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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