
{"id":13264,"date":"2024-05-22T10:20:00","date_gmt":"2024-05-22T10:20:00","guid":{"rendered":"https:\/\/www.sygnaturediscovery.com\/?post_type=webinar-and-podcast&#038;p=13264"},"modified":"2026-01-23T16:04:40","modified_gmt":"2026-01-23T16:04:40","slug":"how-kinetics-experiments-unveil-organelle-complexity","status":"publish","type":"webinar-and-podcast","link":"https:\/\/www.sygnaturediscovery.com\/fr\/webinar-and-podcast\/how-kinetics-experiments-unveil-organelle-complexity\/","title":{"rendered":"How Kinetics Experiments Unveil Organelle Complexity"},"content":{"rendered":"\n<p>Mitochondria behave dynamically and kinetic experiments reveal things static measurements can&rsquo;t. In Episode 3, Tatiana explains how time-resolved data uncovers the complexity of mitochondrial responses and why kinetic readouts are increasingly used in pharmacological evaluations. She discusses how these experiments help identify subtle dysfunction earlier in the discovery process. <\/p>\n\n\n\n<h3 class=\"wp-block-heading has-text-xl-font-size\" style=\"padding-top:var(--wp--preset--spacing--40)\">About Tatiana<\/h3>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-28f84493 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"https:\/\/www.sygnaturediscovery.com\/wp-content\/uploads\/2026\/01\/Tatiana-Rosenstock_Senior-Principal-Scientist_In-Vitro-Neuroscience_Bioscience.webp\" alt=\"\"\/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-left:var(--wp--preset--spacing--40);flex-basis:66.66%\">\n<p>Tatiana Rosenstock has had an exceptional career and has made significant contributions to the field of Neuroscience for 20+ years.&nbsp;Her work has focused on topics such as mitochondrial deregulation, transcription deregulation, and autophagy in neurodegenerative diseases, such as Huntington\u2019s Disease, and Amyotrophic Lateral Sclerosis, and Schizophrenia.&nbsp;&nbsp;<\/p>\n\n\n\n<p>At Sygnature Discovery, Tatiana is a Principal Scientist overseeing various neuroscience-related projects in different sub-areas such as metabolism (mitochondrial function), biomarkers, microglial function and activation, and neuroplasticity. During this period, she has been working with distinct in-vitro models, named&nbsp;iPSC-derived neurons, primary cortical neurons, Alzheimer`s and Parkinson`s disease fibroblasts, neuroblastomas cell lines, tissue and biofluids from transgenics animal models of Alzheimer`s disease.&nbsp;<\/p>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-2-xl-font-size\" style=\"padding-top:var(--wp--preset--spacing--40)\">What You&rsquo;ll Learn<\/h2>\n\n\n\n<ul style=\"padding-bottom:var(--wp--preset--spacing--40)\" class=\"wp-block-list\">\n<li>Why kinetic data is crucial for understanding mitochondrial behavior<\/li>\n\n\n\n<li>How time-dependent changes reveal hidden dysfunction<\/li>\n\n\n\n<li>The role of kinetics in building more predictive CNS models<\/li>\n<\/ul>\n\n\n<section class=\"Pegasus__Container w-full   relative h-fit  text-content-dark mobile-stacking-standard is-layout-flow wp-block-pegasus-container-is-layout-flow\" style=\"   \" >\n\t        \n\t\n\t\t\t\t\t\t\n\t\t        \t\t\n\t\t\t\t\t\t\t\n\t\t\t<div class=\"inner relative h-full is-flex-layout flex flex-col justify-start  w-full\">\n<section x-data=\"PegasusMediaBlock\" \n         class=\"Media object-contain w-full layout h-full\"\n         style=\"\">\n            \n                            \n\n            <div class=\"w-full h-0 relative \" style=\"padding-bottom: 56.25%\">\n            <iframe title=\"#MitochondriaUnlocked_How kinetics experiments unveil the complexities of this organelle (Part 3\/5)\" src=\"https:\/\/www.youtube.com\/embed\/wvEoQ-6oxKk?feature=oembed&amp;rel=0&amp;autoplay=&amp;mute=&amp;muted=&amp;loop=&amp;controls=0\" width=\"640\" height=\"360\" loading=\"eager\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" class=\"video-embed w-full h-full absolute-center \" controls=\"0\"  frameborder=\"0\"><\/iframe>\n        <\/div>\n    \n    <div x-ref=\"videoPlaceholder\" class=\"absolute-center w-full !h-full\" @click=\"playVideo()\">\n        \n\n        <div class=\"preview-play-button absolute-center w-full h-full cursor-pointer\" title=\"Play Full Video\" @click=\"videoModalOpen = true\">\n            <button type=\"button\" class=\"absolute absolute-center w-16 h-16 bg-white\/80 rounded-full flex items-center justify-center\">\n                <span class=\"sr-only\">Play Full Video<\/span>\n                <svg width=\"17\" height=\"20\" viewBox=\"0 0 17 20\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                    <path d=\"M16.5 8.79609C17.1667 9.18099 17.1667 10.1432 16.5 10.5281L1.5 19.1884C0.833335 19.5733 9.70611e-07 19.0922 1.00426e-06 18.3224L1.76136e-06 1.00185C1.79501e-06 0.232054 0.833336 -0.24907 1.5 0.13583L16.5 8.79609Z\" fill=\"#002B46\"\/>\n                <\/svg>\n            <\/button>\n        <\/div>\n    <\/div>\n\n\n                \n            <\/section>\n<\/div>\n\t\t\n\t        <\/section>\n","protected":false},"excerpt":{"rendered":"<p>#MitochonriaUnlocked is a five-part video series from Dr. Tatiana Rosenstock, a neuroscientist at Sygnature Discovery. Across five short episodes, Tatiana shares real-world mitochondrial data and practical guidance to help decision-makers in the CNS disease space understand how, and why, mitochondrial health is becoming central to drug discovery. <\/p>\n","protected":false},"featured_media":13265,"template":"","category":[753,688],"resource_tag":[],"class_list":["post-13264","webinar-and-podcast","type-webinar-and-podcast","status-publish","has-post-thumbnail","hentry","category-neuroscience","category-therapeutic-areas"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How Kinetics Reveal Mitochondrial Complexity<\/title>\n<meta name=\"description\" content=\"Kinetic experiments uncover dynamic mitochondrial behaviour and time\u2011resolved data is essential for identifying early dysfunction.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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